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Rapid mapping and differentiation in ventricular outflow tract arrhythmia using non-contact mapping.
J Interv Card Electrophysiol
June 2017
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Purpose: Ventricular outflow tract arrhythmias (VOTAs) can be successfully treated by catheter ablation. However, it is sometimes difficult to differentiate the origin of VOTAs between the right ventricular outflow tract (RVOT) and the other sites, leading to a long fluoroscopy time and unnecessary radiofrequency applications. This study aimed to clarify distinguishable characteristics of the propagation pattern obtained from non-contact mapping (NCM) for VOTA ablation.
View Article and Find Full Text PDF[Analytical method for the potential distribution of head sphere model under the stimulation of point current source].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
August 2008
The Key Laboratory of High Voltage and New Technology, The Electrical Engineering College, Chongqing University, Chongqing 400044, China.
The 4-layer sphere model of human head was built; the layers from outside to inside represented the scalp, the skull, the CFS and the brain, respectively. The point current source placed on the outmost layer was regarded as the boundary condition, and the method of separation of variables was used to solve the equations. The potential distribution and the current expression were given, and the isopotential-line map and current lines were drawn.
View Article and Find Full Text PDFValidation of the noncontact mapping system in the left atrium during permanent atrial fibrillation and sinus rhythm.
J Am Coll Cardiol
August 2006
Department of Cardiology, St. Bartholomew's Hospital, London, United Kingdom.
Objectives: The aim of this study was to validate noncontact mapping (NCM) in the left atrium (LA) during sinus rhythm and atrial fibrillation (AF).
Background: Understanding the mechanisms of AF is crucial to the development of novel and effective treatments. Noncontact mapping records global electrical activation simultaneously and therefore has the potential to elucidate these mechanisms.
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
Bioorg Med Chem
May 2006
Schrödinger, Inc., 120 West Forty-Fifth Street, 32nd Floor, New York, NY 10036, USA.
We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium channel, KvAP, as a template. We docked a set of known blockers with well-characterized effects on channel function into the lumen of the pore between the selectivity filter and extracellular entrance using a novel docking and refinement procedure incorporating Glide and Prime. Key aromatic groups of the blockers are predicted to form multiple simultaneous ring stacking and hydrophobic interactions among the eight aromatic residues lining the pore.
View Article and Find Full Text PDFSimple, quantitative body surface potential map parameters in the diagnosis of remote Q wave and non-Q wave myocardial infarction.
Can J Cardiol
September 2004
Research Centre, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Quebec.
Background: Body surface potential mapping has been shown to be a useful tool in the diagnosis and localization of remote non-Q wave and Q wave myocardial infarction, but human expertise is required to interpret the maps.
Objective: To identify quantitative body surface potential mapping parameters that could enable a computer-based diagnosis.
Methods: Body surface isopotential maps (63 unipolar leads) were recorded in 86 patients with remote Q wave and 71 patients with remote non-Q wave myocardial infarction.
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