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Optimization of Fermentation Conditions in Ergothioneine Biosynthesis from Ganoderma resinaceum (Agaricomycetes) and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase.
Int J Med Mushrooms
January 2025
Department of Bioengineering, College of Food Science & Institute of Food Biotechnology, South China Agricultural University, Guangzhou 510640, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510640, China.
Ganoderma resinaceum is a traditional mushroom that contains natural products, including ergothioneine (EGT), which has powerful antioxidant properties in the human body. To increase EGT yield from G. resinaceum, the optimal carbon and nitrogen sources in the culture medium were determined as 20 g/L sucrose and 4 g/L NH4Cl, respectively.
View Article and Find Full Text PDFTheoretical Study of Antioxidant and Prooxidant Potency of Protocatechuic Aldehyde.
Int J Mol Sci
January 2025
Institute for Information Technologies Kragujevac, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
In this study, the antioxidant and prooxidant potency of protocatechuic aldehyde (PCA) was evaluated using density functional theory (DFT). The potency of direct scavenging of hydroperoxyl (HOO) and lipid peroxyl radicals (modeled by vinyl peroxyl, HC=CHOO) involved in lipid peroxidation was estimated. The repair of oxidative damage in biomolecules (lipids, proteins and nucleic acids) and the prooxidant ability of PCA phenoxyl radicals were considered.
View Article and Find Full Text PDFDiscovery, Characterization, and Anti-XOD Activity of Calcium Metallophore from .
Org Lett
January 2025
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
In this work, coixalkyne A (), a natural polynuclear calcium complex with a novel cross-shaped molecular architecture, was isolated from L. along with the undescribed analogue coixalkyne B (). Their structures were identified by means of NMR spectroscopy, ECD calculations, and single-crystal X-ray diffraction.
View Article and Find Full Text PDFOatmeal and wheat flour as the sources of thyroid peroxidase and proinflammatory enzymes modulators in the prevention of thyroid diseases.
Sci Rep
January 2025
Department of Biochemistry and Food Chemistry, University of Life Sciences, Skromna Str. 8, Lublin, 20-704, Poland.
Polyphenolic plant compounds possess nutritional and pro-healthy potential, reducing the risk of auto-inflammatory and neoplastic diseases. However, their interference with the progression of thyroid gland dysfunctions has remained largely unaddressed. For this purpose, we combined the analyses of phenolic content and antioxidative activity with the thyroid peroxidase (TPO), lipoxygenase (LOX), xanthine oxidase (XO) and cyclooxygenase-2 (COX-2) activity assays, isobolographic approach and the estimation of thyroid cancer cells' proliferation and motility in vitro.
View Article and Find Full Text PDFExploring the separation, characterization and antioxidant activity of proteins and peptides from selected seagrasses in Palk Bay region of Tamil Nadu in India.
Int J Biol Macromol
January 2025
Department of Biotechnology, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India. Electronic address:
In this study, five seagrass species Halodule uninervis, Thalassia hemprichii, Enhalus acoroides, Cymodocea serrulata, and Syringodium isoetifolium collected from the Mandapam coastal region of Rameswaram (Palk Bay region), Tamil Nadu, India, were selected to identify the antioxidant-rich proteins/peptides. The primary objective was to identify the proteins/peptides present in these seagrass filtrates extracted by using four different pH-based buffer extracts and to assess their antioxidant activity. Among the various buffer extracts, 0.
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