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Montelukast potentiates the relaxing effect of nifedipine in the porcine myometrium.
Pol J Vet Sci
September 2024
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, Poland.
This study analysed the influence of montelukast (MON), a cysteinyl leukotriene receptor antagonist, and nifedipine, an L-type voltage-gated Ca2+ channel blocker, on the contractility of the porcine uterine smooth muscle. Myometrial strips were collected from the sexually immature (n=8), cyclic (12-14 days of the oestrous cycle; n=8) and pregnant (27-28 days of pregnancy; n=8) gilts and stimulated with a) MON or nifedipine at concentrations of 10-8-10-4 M and b) increasing concentrations of nifedipine after previous administration of MON at a concentration of 10-4 M. The changes in the tension, amplitude and frequency of contractions were determined with the Hugo Sachs Elektronik equipment for measuring isometric contractions.
View Article and Find Full Text PDFBiophysical mechanisms underlying tefluthrin-induced modulation of gating changes and resurgent current generation in the human Na1.4 channel.
Pestic Biochem Physiol
March 2024
Department of Physiology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:
Human skeletal muscle contraction is triggered by activation of Na1.4 channels. Na1.
View Article and Find Full Text PDFA review of the therapeutic potential of the cysteinyl leukotriene antagonist Montelukast in the treatment of bronchiolitis obliterans syndrome following lung and hematopoietic-stem cell transplantation and its possible mechanisms.
Ther Adv Respir Dis
March 2024
Rajaei Cardiovascular Medical and Research Institute, Valiasr Ave-Niyayesh Intersection, Tehran 199561-14331, Iran.
Lung and hematopoietic stem cell transplantation are therapeutic modalities in chronic pulmonary and hematological diseases, respectively. One of the complications in these patients is the development of bronchiolitis obliterans syndrome (BOS). The efficacy and safety of available treatment strategies in BOS remain a challenge.
View Article and Find Full Text PDFIn vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters.
Life Sci
May 2022
Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain. Electronic address:
Aims: Nitric oxide (NO) and hydrogen sulfide (HS) are involved in nerve-mediated corpus cavernosum (CC) relaxation. Expression of phosphodiesterase type 5 (PDE5) and type 4 (PDE4), cyclic guanosine monophosphate (cGMP)- and cyclic adenosine monophosphate (cAMP)-specific, respectively, has been described and PDE5- and PDE4-inhibitors induce cavernous smooth muscle relaxation. Whereas the NO/cGMP signaling pathway is well established in penile erection, the cAMP-mediated mechanism is not fully elucidated.
View Article and Find Full Text PDFThe effect of pulmonary surfactant on the airway smooth muscle after lipopolysaccharide exposure and its mechanisms.
Physiol Res
December 2019
Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.
Article Synopsis
- Pulmonary surfactant can relax airway smooth muscle (ASM), highlighting its potential role in respiratory issues like asthma and COPD.
- Research showed that lipopolysaccharide (LPS), a bacterial component, affects ASM reactivity, with some tests done on guinea pig models.
- While surfactant provides a relaxing effect on ASM, it does not counteract contractions caused by LPS, suggesting involvement of other factors like prostanoids, and receptors for leukotrienes and histamine in this process.
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