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Two scientific perspectives on nerve signal propagation: how incompatible approaches jointly promote progress in explanatory understanding.
Hist Philos Life Sci
November 2024
Amsterdam Neuroscience, Department of Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
We present a case study of two scientific perspectives on the phenomenon of nerve signal propagation, a bio-electric and a thermodynamic perspective, and compare this case with two accounts of scientific perspectivism: those of Michela Massimi and Juha Saatsi, respectively. We demonstrate that the interaction between the bio-electric perspective and the thermodynamic perspective can be captured in Saatsi's terms of progress in explanatory understanding. Using insights from our case study, we argue that both the epistemic and pragmatic dimensions of scientific understanding are important for increasing explanatory understanding of phenomena.
View Article and Find Full Text PDFModeling somatic computation with non-neural bioelectric networks.
Sci Rep
December 2019
Allen Discovery Center, 200 College Ave., Tufts University, Medford, MA, 02155, USA.
The field of basal cognition seeks to understand how adaptive, context-specific behavior occurs in non-neural biological systems. Embryogenesis and regeneration require plasticity in many tissue types to achieve structural and functional goals in diverse circumstances. Thus, advances in both evolutionary cell biology and regenerative medicine require an understanding of how non-neural tissues could process information.
View Article and Find Full Text PDFA Formal Approach for Scalable Simulation of Gastric ICC Electrophysiology.
IEEE Trans Biomed Eng
December 2019
Objective: Efficient and accurate organ models are crucial for closed-loop validation of implantable medical devices. This paper investigates bio-electric slow wave modeling of the stomach, so that gastric electrical stimulator (GES) can be validated and verified prior to implantation. In particular, we consider high-fidelity, scalable, and efficient modeling of the pacemaker, Interstitial cells of Cajal (ICC), based on the formal hybrid input output automata (HIOA) framework.
View Article and Find Full Text PDFIL-1 provokes electrical abnormalities in rat atrial myocardium.
Int Immunopharmacol
September 2015
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Using a micro-electrode technique we studied the effects of interleukin 1α and interleukin 1β on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching. Perfusion with interleukin 1α increased the duration of the action potential at the level of 90% re-polarization. Stretch induced tachy-arrhythmia in the presence of interleukin 1α is mainly regulated via stretch increased nitric oxide production, while the ionotropic effect of the interleukin-1α during stretching is not pronounced.
View Article and Find Full Text PDFEffects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching.
Immunol Lett
September 2015
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Sts, Cyril and Methodius" University, P.O. Box 162, Skopje 1000, Macedonia. Electronic address:
Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90% re-polarization. Perfusion with interleukin-2 resulted in appearance of frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia pacing into normal rhythms.
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