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Improving the binding affinity of plastic degrading cutinase with polyethylene terephthalate (PET) and polyurethane (PU); an in-silico study.
Heliyon
January 2025
Biomass Conversion and Bioproducts Laboratory, Center for Bioenergy, School of Chemical & Biotechnology, SASTRA Deemed University, Thirumalaisamudram, Tamil Nadu, India.
Plastic pollution is a worrying problem, and its degradation is a laborious process. Although enzymatic plastic breakdown is a sustainable method, drawbacks such as numerous plastic kinds of waste make the degradation challenging. Therefore, a multi-plastic degrading (MPD) enzyme becomes necessary.
View Article and Find Full Text PDFMulti-site enzymatic repairing amplification (MSERA) enables ultrasensitive detection of terminal deoxynucleotidyl transferase activity.
Chem Commun (Camb)
January 2025
Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
A novel multi-site enzymatic repairing amplification strategy is developed for high-sensitive terminal deoxynucleotidyl transferase quantification through combining enzymatic repairing amplification and lesion base-involved terminal extension. This method may provide a sensitive and flexible tool for molecular diagnosis and drug discovery.
View Article and Find Full Text PDFBuilding Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.
Angew Chem Int Ed Engl
January 2025
University of Oxford, Chemistry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
The catalytic action of enzymes of a cascade trapped within a mesoporous electrode material is simultaneously energized, controlled and observed through the efficient, reversible electrochemical NAD(P)(H) recycling catalyzed by one of the enzymes. In their nanoconfined state, nicotinamide cofactors are tightly channeled current carriers, mediating multi-step reactions in either direction (oxidation or reduction) with a rapid response time. By incorporating a hydrogen‑borrowing enzyme pair, the internal action of which opposes the external voltage bias driving oxidation or reduction, a reduction process can be performed under overall oxidizing conditions, and vice versa.
View Article and Find Full Text PDFImproving the Long-term Enantioselectivity of a Silicon-Carbon Bond-Forming Enzyme.
Chemistry
January 2025
Karlsruhe Institute of Technology, Institute for biological interfaces 1 (IBG-1), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, GERMANY.
Enantioselectivity is a key advantage of enzymatic catalysis. Understanding the most important factors influencing enantioselectivity necessitates thorough investigation for each specific enzyme. In this study, we explore various approaches to optimize reaction conditions for organosilicon production using an immobilized Cytochrome C recently tailored via directed evolution.
View Article and Find Full Text PDFYAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer.
Cell Death Differ
January 2025
Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Hyperactivation of the YAP/TEAD transcriptional complex in cancers facilitates the development of an immunosuppressive tumor microenvironment. Herein, we observed that the transcription factor SP1 physically interacts with and stabilizes the YAP/TEAD complex at regulatory genomic loci in colorectal cancer (CRC). In response to serum stimulation, PKCζ (protein kinase C ζ) was found to phosphorylate SP1 and enhance its interaction with TEAD4.
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