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Gallic acid: a dietary metabolite's therapeutic potential in the management of atherosclerotic cardiovascular disease.
Front Pharmacol
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways and minimally impact other diseases associated with ASCVD. Moreover, interactions of these drugs can cause toxic reactions.
View Article and Find Full Text PDFDifferentiation of Atherosclerotic Carotid Plaque Components With Dual-Energy Computed Tomography.
Invest Radiol
January 2025
From the Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (M.A., J.B., T.F., A.A.P., M.E.K.); CARIM, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands (M.A., J.B., M.J.J.G., W.H.M., R.J.v.O., M.E.K.); Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands (M.J.J.G.); Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences: Atherosclerosis & Ischemic Syndrome; Amsterdam Infection and Immunity: Inflammatory Diseases; Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands (M.J.J.G.); Department of Neurology, Zuyderland Medical Center, Heerlen, the Netherlands (T.H.C.M.L.S.); Department of Neurology, Zuyderland Medical Center, Sittard, the Netherlands (N.P.v.O.); Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, the Netherlands (J.-W.H.C.D.); Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands (W.H.M.); Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands (R.J.v.O.); and School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands (A.A.P.).
Objectives: Carotid plaque vulnerability is a strong predictor of recurrent ipsilateral stroke, but differentiation of plaque components using conventional computed tomography (CT) is suboptimal. The aim of our study was to evaluate the ability of dual-energy CT (DECT) to characterize atherosclerotic carotid plaque components based on the effective atomic number and effective electron density using magnetic resonance imaging (MRI) and, where possible, histology as the reference standard.
Materials And Methods: Patients with recent cerebral ischemia and a ≥2-mm carotid plaque underwent computed tomography angiography and MRI.
Evaluation of circadian rhythm and prognostic variability pre-and post-CEA or CAS treatment in patients with carotid artery stenosis.
Front Neurol
January 2025
Department of Vascular Neurosurgery, New Era Stroke Care and Research Institute, The PLA Rocket Force Characteristic Medical Center, Beijing, China.
Objective: Carotid artery stenosis, primarily caused by atherosclerosis, is a major risk factor for ischemic stroke. Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are established interventions to reduce stroke risk and restore cerebral blood flow. However, the effect of these treatments on circadian rhythms, and their influence on stroke recovery, remains underexplored.
View Article and Find Full Text PDFCarotid artery atherosclerotic stenosis is an important annual cause of stroke in the United States. Moreover, the incidence of carotid artery stenosis is significantly increasing due to the widespread popularity of high fat and high salt diets, sedentary lifestyles, and the increasing age of the population. Of major importance to cardiovascular specialists is the fact that individuals with atherosclerotic carotid artery stenosis can have a prevalence of atherosclerotic coronary artery disease as high as 50 to 75%.
View Article and Find Full Text PDFInterrelation between domains of functioning and white matter hyperintensities in geriatric memory clinic patients: a holistic approach through network analysis.
Aging Ment Health
January 2025
Internal Medicine, Geriatric Medicine section, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Objectives: To explore interrelations between cognitive, physical, affective, and daily functioning, quality of life and white matter hyperintensities (WMH) in a geriatric memory clinic sample.
Method: Participants received brain imaging, comprehensive geriatric assessment and neuropsychological evaluation including measurements of cognitive, physical, affective, and daily functioning and health-related quality of life. Data was analyzed using multiple linear regressions and network analysis using (moderated) mixed graphical models.
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