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Severe hyponatremia with consciousness disturbance after receiving SARS-CoV-2 mRNA vaccination.
Endocrinol Diabetes Metab Case Rep
July 2023
Department of Metabolism, Akita Red Cross Hospital, Akita, Japan.
Summary: There are very few reports of syndrome of inappropriate antidiuresis hormone secretion (SIADH) after receiving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. Herein, we present the case of an 84-year-old woman who developed severe hyponatremia following the second administration of the SARS-CoV-2 mRNA vaccine. The patient presented with nausea, vomiting, and headache.
View Article and Find Full Text PDFIntractable hyponatremia secondary to syndrome of inappropriate antidiuresis complicated with empty sella: A case report.
Medicine (Baltimore)
April 2023
Department of Intensive Care Medicine, Liyuan Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Rationale: Hyponatremia is a common electrolyte disorder in elderly critically ill patients, and it may be associated with poor outcomes, higher morbidity, and mortality. Syndrome of inappropriate antidiuresis (SIAD) is one of the main causes of hyponatremia, with an insidious onset that is highly misdiagnosed. Primary empty sella lesions are specific, mostly asymptomatic, and easily overlooked.
View Article and Find Full Text PDFThe Long Way of Oxytocin from the Uterus to the Heart in 70 Years from Its Discovery.
Int J Mol Sci
January 2023
Department of Biomedical Sciences and Human Oncology, Section of Pharmacology, School of Medicine, University of Bari "Aldo Moro", P.za G. Cesare 11, 70100 Bari, Italy.
The research program on oxytocin started in 1895, when Oliver and Schafer reported that a substance extracted from the pituitary gland elevates blood pressure when injected intravenously into dogs. Dale later reported that a neurohypophysial substance triggers uterine contraction, lactation, and antidiuresis. Purification of this pituitary gland extracts revealed that the vasopressor and antidiuretic activity could be attributed to vasopressin, while uterotonic and lactation activity could be attributed to oxytocin.
View Article and Find Full Text PDFPerioperative water and electrolyte balance and water homeostasis regulation in children with acute surgery.
Pediatr Res
October 2023
Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum 5B, Stockholm, Sweden.
Background: Hospital-acquired hyponatremia remains a feared event in patients receiving hypotonic fluid therapy. Our objectives were to assess post-operative plasma-sodium concentration and to provide a physiological explanation for plasma-sodium levels over time in children with acute appendicitis.
Methods: Thirteen normonatremic (plasma-sodium ≥135 mmol/L) children (8 males), median age 12.
Ratio Profile: Physiologic Approach to Estimating Appropriate Intravenous Fluid Rate to Manage Hyponatremia in the Syndrome of Inappropriate Antidiuresis.
Kidney360
December 2022
Internal Medicine, SUNY Downstate, New York, New York.
A hyponatremic patient with the syndrome of inappropriate antidiuresis (SIAD) gets normal saline (NS), and the plasma sodium decreases, paradoxically. To explain, desalination is often invoked: if urine is more concentrated than NS, the fluid's salts are excreted while some water is reabsorbed, exacerbating hyponatremia. But comparing concentrations can be deceiving.
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