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Cytophotometric DNA measurements in medullary thyroid carcinoma.
Cancer
May 1990
Department of Pathology, Hospital Universitario, Virgen de la Macarena, Sevilla, Spain.
The prognostic significance of objectively measured karyometric variables (ploidy pattern, nuclear roundness, area, elongation, chromatin texture, and nearest nucleus distance) was investigated in relation to clinical (stage and type of disease) and morphologic (histologic patterns) variables in 27 patients with the diagnosis of medullary thyroid carcinoma (MTC). The DNA and karyometric measurements of Feulgen-stained nuclei were made with a video cytometry system. The five-year and ten-year adjusted survival rates were 74.
View Article and Find Full Text PDFBlood vessel endothelia of the cerebral white matter of rats exposed to hypoxia. Karyometric and cytophotometric evaluation.
Exp Pathol
July 1991
Department of Neurology, Laboratory of Neuropathology, Medical School Poznań, Poland.
Hypoxic hypoxia is used as one of the models for examining the unfavourable effect of oxygen deficit on the nervous system. Since some morphological studies concerning the effect of hypoxia on the central nervous system have given consideration to perivascular lesion zones and glia alterations in the white matter, the present evaluation of the effect of hypoxia has been directed to vascular endothelia of the white matter. Examinations were conducted on adult rats of the Wistar strain which were exposed to acute hypoxia by being placed in a gas mixture containing 2% O2 or to moderate hypoxia - in a gas mixture containing 7% O2.
View Article and Find Full Text PDFKaryometric and cytophotometric studies of the oligodendroglia in the corpus callosum of the rat after hypoxia.
Exp Pathol
April 1989
Department of Neurology, Medical School Poznań, Poland.
Karyometric and cytophotometric investigations were conducted using an automatic analyser "Morphoquant" on oligodendroglial nuclei of corpus callosum following acute or moderate hypoxia in Wistar rats. Results of our studies demonstrated karyometric changes in nuclei of oligodendroglia cells after hypoxia, with deviations distinct in the early and late period after exposure to hypoxia. Cytophotometric analysis of a relative DNA content in cell nuclei of oligodendroglia demonstrated an increased extinction of DNA in the early period and a decreased extinction in the late period after acute or moderate hypoxia.
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