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Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission.
PLoS Negl Trop Dis
January 2025
Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
Background: Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there is a critical need for developing highly sensitive and specific tools to monitor transmission in near-elimination settings. Although antibody detection is a promising approach, it is usually unable to discriminate active infections from past ones.
View Article and Find Full Text PDFThe Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research.
Metabolites
January 2025
Sport Coaching College, Beijing Sport University, Beijing 100084, China.
Objective: This study aimed to explore the molecular response mechanisms of differential blood metabolites before and after 8 weeks of threshold and polarized training models using metabolomics technology combined with changes in athletic performance.
Methods: Twenty-four male rowers aged 14-16 were randomly divided into a THR group and a POL group (12 participants each). The THR group followed a threshold training model (72%, 24%, and 4% of training time in low-, moderate-, and high-intensity zones, respectively), while the POL group followed a polarized training model (78%, 8%, and 14% training-intensity distribution).
Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.
Proc Natl Acad Sci U S A
January 2025
National Institute of Biological Sciences, Beijing 102206, China.
Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear.
View Article and Find Full Text PDFMorpho-physiological digestive features of genetically closely related sympatric lacustrine whitefish forms with different feeding habits.
Fish Physiol Biochem
January 2025
Institute of Agrifood Research and Technology (IRTA), Centre de La Ràpita, Crta. Poble Nou del Delta Km 5.5, 43540, la Ràpita, Spain.
The effect of different feeding habits on gut morphology and digestive function has been intensively studied during the last decades but sympatric closely related fishes are relatively rare objects of such studies. In the present study, we have identified both morphological and physiological changes in the digestive system of a sympatric pair of whitefish represented by "normal" Coregonus lavaretus pidschian (benthivorous) and "dwarf" C. l.
View Article and Find Full Text PDFAstaxanthin-loaded PLGA nanoparticles inhibit survival of MKN-45 gastric cancer cell line by modulating JAK2/STAT3/mTOR/PI3K pathway.
BMC Cancer
January 2025
Department of Cellular and Molecular Biology, Lahijan Branch, Islamic Azad University, Lahijan, Iran.
Background/aims: Gastric cancer (GC) is a significant global health issue with high incidence rates and poor prognoses, ranking among the top prevalent cancers worldwide. Due to undesirable side effects and drug resistance, there is a pressing need for the development of novel therapeutic strategies. Understanding the interconnectedness of the JAK2/STAT3/mTOR/PI3K pathway in tumorigenesis and the role of Astaxanthin (ASX), a red ketocarotenoid member of xanthophylls and potent antioxidant and anti-tumor activity, can be effective for cancer treatments.
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