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Investigating the Relationship Between Anti-seizure Medications and Bleeding Disorders: A Comprehensive Review of the Current Literature.
Drugs Real World Outcomes
January 2025
Kabul University of Medical Sciences, Kabul, Afghanistan.
Anti-seizure medications (ASMs) are specific types of anticonvulsants used to treat epileptic seizures. However, several studies have shown an association between ASMs and an increased risk of hematological disorders, such as thrombocytopenia, aplastic anemia, and platelet function disorders leading to prolonged bleeding times. This review explores the existing literature on this topic, investigating a wide variety of ASMs, ranging from first-generation medications to newer ones.
View Article and Find Full Text PDFCo-Treatment with Cranberry and Vitamin-C Mitigates Reproductive Toxicities Induced by Phenobarbital in Male Rats.
Cell Physiol Biochem
December 2024
Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Background/aims: Phenobarbital (PB), commonly used for epilepsy management, is associated with testicular dysfunction after prolonged use. This study aimed to evaluate the ameliorative effects of cranberry (CB) and vitamin C (Vit-C) on PB-induced reproductive toxicity in rats.
Methods: Forty male Wistar rats were divided into five groups.
Comparative efficacy and safety of second-line medications for status epilepticus: A network meta-analysis.
Medicine (Baltimore)
November 2024
Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, China.
Background: To systematically review the efficacy and safety of second-line medications for status epilepticus (SE).
Methods: Electronic searches were conducted in PubMed, Embase, and The Cochrane Library for randomized controlled trials of second-line medications for SE from inception to January 2024. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies.
allele frequencies and implications for pharmacogenetics in the Kuwaiti population.
Front Pharmacol
October 2024
Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
Unlabelled: This study explores the frequency of human leukocyte antigen (HLA) genes, particularly alleles, within the Kuwaiti population. We aim to identify alleles with known associations to adverse drug reactions (ADRs) based on existing literature. We focus on the gene due to its well-documented associations with severe cutaneous adverse reactions and the extensive pharmacogenetic research supporting its clinical relevance.
View Article and Find Full Text PDFEfficacy and safety of rectal chloral hydrate for pediatric procedural sedation: A systematic review and meta-analysis.
Medicine (Baltimore)
August 2024
Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: To evaluate the efficacy and safety of rectal chloral hydrate (CH) in pediatric procedural sedation.
Methods: Seven electronic databases and 3 clinical trials registry platforms were searched, and the deadline was August 2022. Randomized controlled trials evaluating the efficacy and safety of rectal CH in pediatric procedural sedation were included by 2 reviewers.
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