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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation.
Mol Metab
January 2025
Section of Endocrinology and Investigative Medicine, Imperial College London, United Kingdom. Electronic address:
Objective: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. We explored the extent of pancreatic GIPR functional desensitisation with sustained agonist exposure.
View Article and Find Full Text PDFBackground: Cognitive resilience (CR) refers to the continuum from worse to better-than-expected cognition, given the degree of neuropathology. Understanding mechanisms underlying CR could inform discovery of novel targets for dementia prevention; however, specific metabolic pathways underlying CR are yet to be elucidated.
Methods: Our study included 484 deceased participants (mean age at death =91 years, 70.
Public Health.
Alzheimers Dement
December 2024
Hospital Clínico Universidad de Chile, Santiago, Region Metropolitana, Chile.
Background: Cardiovascular risk factors (CVRF) are among the main modifiable risk factors for dementia in Latin America (LA). Therefore, improving cardiovascular health (CVH) is one of the main objectives of the LatAm-FINGERS trial, the largest non-pharmacological (lifestyle improvement) randomized trial in LA. But, to fully comprehend CVH it is necessary to explore its relation with the social determinants of health (SDH), that are closely associated with lifestyle.
View Article and Find Full Text PDFEffect of Total and Partial Meal Replacements on Factors Related to Glucose Metabolism: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Nutr Rev
January 2025
Department on Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd 8915173149, Iran.
Context: Although some evidence shows the beneficial effects of meal replacements (MRs) on glucose metabolism as one of the main factors of diabetes, there are still no comprehensive findings in this field.
Objective: We investigated the effects of total and partial MRs on fasting blood sugar (FBS), insulin, glycated hemoglobin (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) in this comprehensive study and meta-analysis.
Data Sources: To find pertinent randomized controlled trials (RCTs) up to March 2024, databases including PubMed/Medline, Web of Science, Scopus, and Embase were searched.
The relationship between whole blood iron and fasting blood glucose in community-dwelling elderly people: a cross-sectional study.
J Health Popul Nutr
January 2025
School of Medicine, Taizhou University, No.1139, Shifu Avenue, Jiaojiang, 318000, Zhejiang, China.
Iron overload increases fasting blood glucose level in mice, leading to insulin insensitivity. However, no such relationship has been shown in the population. The relationship between whole blood iron levels and fasting blood glucose levels remained unclear.
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