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Testicular sex cord-stromal tumors in mice with constitutive activation of PI3K and loss of Pten.
Carcinogenesis
December 2024
Department of Surgery (RMH), The University of Melbourne, Parkville, Australia.
Testicular tumors are the most common malignancy of young men and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one third of testicular cancers. To investigate the role of the PI3K pathway in transforming stem-like cells in the testis, we investigated tumors derived from mice with post-natal, constitutive activation of PI3K signaling and homozygous deletion of tumor suppressor Pten, targeted to nestin expressing cells.
View Article and Find Full Text PDF[Ovarian collision tumor with postmenopausal hyperandrogenism: a case report].
Zhonghua Nei Ke Za Zhi
December 2024
Department of Endocrinology, the First Medical Center, Chinese PLA General Hospital, Beijing100039, China.
Diagnostic pitfalls in ovarian androgen-secreting tumors in postmenopausal women with rapidly progressed severe hyperandrogenism.
Post Reprod Health
November 2024
Obstetrics and Gynecology Unit, ASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, Italy.
Article Synopsis
- The study discusses two rare cases of postmenopausal women experiencing rapid virilization and high testosterone levels, despite negative imaging results for ovarian masses.
- Both patients underwent hormone profiling and inconclusive imaging, leading to a suspicion of ovarian tumors, prompting surgical intervention through laparoscopic oophorectomy.
- Histological examination after surgery confirmed Leydig cell tumors in one patient and thecoma in the other, with testosterone levels normalizing and symptoms improving post-surgery, emphasizing the need for thorough evaluation of androgen excess in postmenopausal women.
A molecular and immunohistochemical study of 37 cases of ovarian Sertoli-Leydig cell tumor.
Virchows Arch
November 2024
Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Article Synopsis
- This study analyzes 37 ovarian Sertoli-Leydig cell tumors (SLCT) with a focus on their morphology, immunohistochemistry, and molecular features, categorizing them into well, moderately, and poorly differentiated tumors.
- High levels of sex cord markers were found, along with variable expression of other markers, and notable mutations like DICER1 (54.5%) and FOXL2 (6%) were identified, suggesting important diagnostic and predictive implications.
- Differences in mRNA expression profiles between DICER1 and non-DICER1 tumors highlight the distinct molecular characteristics of SLCTs, indicating that well-differentiated tumors could represent a unique subtype apart from the others.
Multiple Endocrine Neoplasia with Multiple PGLs in Two Boxer Dogs: Morphological Features, Immunohistochemical Profile and SDHD Gene Mutation Screening.
Vet Sci
November 2024
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Article Synopsis
- * The tumors included various types, such as aortic and carotid body PGLs, thyroid cancer, and other growths, with one aortic body tumor showing malignant traits.
- * No genetic mutations were found in the SDHD gene subunits analyzed, indicating that other genetic factors may contribute to tumor development, prompting further research in this area.
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