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Refractory seizures in a dialysis patient and a vitamin consigned to oblivion.
Clin Nephrol Case Stud
September 2023
Medical Sub-specialties Institute, Department of Nephrology.
Intradialytic breakthrough seizures refractory to multiple classes of antiepileptic medications are not common and can be due to many different reasons. Pyridoxine deficiency is an under-recognized cause of such seizures and frequently missed in clinical practice. Many factors specifically related to dialysis can lead to pyridoxine deficiency and in turn can contribute to refractory seizures.
View Article and Find Full Text PDFOral Levodopa, Vitamin B6, and Polyneuropathy: A Case Series.
Can J Neurol Sci
May 2024
Université Laval, Québec, Canada.
Refractory Seizures Secondary to Vitamin B6 Deficiency in Parkinson Disease: The Role of Carbidopa-Levodopa.
Case Rep Neurol
June 2022
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Carbidopa-levodopa has been used for more than 50 years in the treatment of Parkinson disease (PD) and other movement disorders. Pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 (pyridoxine), is involved in the decarboxylation of levodopa to dopamine; carbidopa, which is combined with levodopa to reduce peripheral levodopa conversion and minimize peripheral dopamine side effects, binds irreversibly with PLP. As a result, carbidopa-levodopa may cause vitamin B6 deficiency and associated sequelae, including seizures, especially in high doses.
View Article and Find Full Text PDFReply: Vitamins B6 and B12, levodopa, and their complex interactions in patients with Parkinson's disease.
Brain
September 2022
Department of Neurology, Centro Hospitalar Universitário do Porto (CHUPorto), 4099-001 Porto, Portugal.
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