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Measurement properties of instruments to assess insight in psychosis: A systematic review protocol.
PLoS One
January 2025
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Introduction: Insight in psychosis, defined as a patient's awareness and judgment of their mental illness, is a complex and evolving concept. Historically, the absence of insight was considered a defining characteristic of psychosis, but recent decades have seen the development of structured tools for its assessment. This systematic review aims to critically appraise the measurement properties of instruments used to assess insight in individuals with schizophrenia spectrum, bridging the gap between theoretical conceptualization and clinical practice.
View Article and Find Full Text PDFMatched Unrelated Donor Hematopoietic Cell Transplantation: Increased Usage and Improvements in Clinical Outcomes in Canada.
Curr Oncol
December 2024
CancerCare Manitoba, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.
In allogeneic hematopoietic cell transplantation (HCT), a minority of patients have access to a suitable human leukocyte antigen (HLA)-matched related donor (MRD). To fill this gap, matched unrelated donors (MUDs) are an increasingly selected donor source. Usage and outcomes after MUD HCT for Canada are not described.
View Article and Find Full Text PDFIdentification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations.
Sci Rep
January 2025
Laboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Cadi Ayyad University, BP 2390, 40000, Marrakech, Morocco.
TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of cancers. Therefore, this study aims to disover potential TMPRSS4 inhibitors that have better binding affinity than the approved inhibitors: 2-hydroxydiarylamide and tyroserleutide.
View Article and Find Full Text PDFEffects of psychedelics on opioid use disorder: a scoping review of preclinical studies.
Cell Mol Life Sci
January 2025
Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT, 06511, USA.
The current opioid crisis has had an unprecedented public health impact. Approved medications for opioid use disorder (OUD) exist, yet their limitations indicate a need for innovative treatments. Limited preliminary clinical studies suggest specific psychedelics might aid OUD treatment, though most clinical evidence remains observational, with few controlled trials.
View Article and Find Full Text PDFWhen agricultural waste are promoted as nutritional sources in rabbit nutrition.
Trop Anim Health Prod
January 2025
Department of Morphology, Federal University of Santa Maria, Av. Roraima - 1000, Cidade Universitária, Santa Maria, RS, 97105-900, Brazil.
This study was carried out with the objective of evaluating the use of sweet potato vines (SPV) in replacement of alfalfa hay in diets for growing rabbits. For this, data on: performance, composition and color of the meat, digestive enzymes, intestinal morphology and economic viability were analyzed. Fifty New Zealand White rabbits were used, weaned at 35 days with a body weight of ± 585 g, for 49 days.
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