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Integrating biomarkers for hemostatic disorders into computational models of blood clot formation: A systematic review.
Math Biosci Eng
December 2024
Laboratory of Optimization, Design, and Advanced Control, School of Chemical Engineering, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
In the pursuit of personalized medicine, there is a growing demand for computational models with parameters that are easily obtainable to accelerate the development of potential solutions. Blood tests, owing to their affordability, accessibility, and routine use in healthcare, offer valuable biomarkers for assessing hemostatic balance in thrombotic and bleeding disorders. Incorporating these biomarkers into computational models of blood coagulation is crucial for creating patient-specific models, which allow for the analysis of the influence of these biomarkers on clot formation.
View Article and Find Full Text PDFTheoretical Study of Antioxidant and Prooxidant Potency of Protocatechuic Aldehyde.
Int J Mol Sci
January 2025
Institute for Information Technologies Kragujevac, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
In this study, the antioxidant and prooxidant potency of protocatechuic aldehyde (PCA) was evaluated using density functional theory (DFT). The potency of direct scavenging of hydroperoxyl (HOO) and lipid peroxyl radicals (modeled by vinyl peroxyl, HC=CHOO) involved in lipid peroxidation was estimated. The repair of oxidative damage in biomolecules (lipids, proteins and nucleic acids) and the prooxidant ability of PCA phenoxyl radicals were considered.
View Article and Find Full Text PDFCharacterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics.
Carbohydr Polym
March 2025
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida Tampa, FL 33620, USA. Electronic address:
Clostridioides difficile (C. difficile) infection (CDI) is a life-threatening healthcare-associated infection occurring worldwide. C.
View Article and Find Full Text PDFInhibition of urate induced pyroptosis and reabsorption transporters overexpression in human renal tubular epithelial cells by low molecular weight fucoidan, as well as its anticoagulation and antioxidation.
Int J Biol Macromol
January 2025
College of Chemistry and Environmental Sciences, Guangdong Ocean University, Zhanjiang 524088, China. Electronic address:
Low molecular weight fucoidan (LMWF) has been proved to be more potent than its prototype, many degradation methods have been used to prepare LMWF. This study is conducted to further explore the biological activities of LMWF prepared by ultrasound based on anticoagulation, antioxidation, and inhibition of urate induced pyroptosis and reabsorption transporters overexpression in human renal tubular epithelial cells. Data revealed that ultrasound successfully degraded fucoidan to be LMWF, the product treated for no more than 2.
View Article and Find Full Text PDFDevelopment of Amniotic Epithelial Stem Cells Secretome-Loaded Inverse Electron Demand Diels-Alder-Cross-Linked Hydrogel as a Potential Immunomodulatory Therapeutical Tool.
ACS Appl Mater Interfaces
January 2025
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, 00014 Helsinki, Finland.
Article Synopsis
- Amniotic epithelial stem cells (AEC) have regenerative potential, particularly through their conditioned medium (AEC-CM), which shows immunomodulatory and regenerative effects.
- A novel hydrogel made from hyaluronic acid and polyethylene glycol was developed to encapsulate AEC-CM, with features like fast cross-linking and sustained growth factor release over 14 days.
- Studies demonstrate that the encapsulated AEC-CM significantly enhances the suppression of peripheral blood mononuclear cells and promotes a shift towards the beneficial M2 macrophage phenotype, suggesting its viability as an immunomodulatory treatment for tissue regeneration.
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