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Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke.
Commun Biol
January 2025
Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA.
As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent. We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet.
View Article and Find Full Text PDFBidirectional effect modifications of temperature and PM on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021.
Ecotoxicol Environ Saf
January 2025
Center for Clinical and Epidemiologic Research, Beijing An Zhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; National Clinical Research Center of Cardiovascular Diseases, Beijing, China; The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China; The Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China. Electronic address:
Background: Ambient temperatures and PM can trigger myocardial infarction (MI), while little is known about the complex interplay between these two factors on MI, especially morbidity.
Objectives: To investigate bidirectional effect modifications of temperature and PM on MI morbidity and mortality.
Methods: A time-stratified case-crossover study was conducted utilizing high-resolution data of temperature and PM, along with 498,077 MI cases from the citywide registry in Beijing, China from 2007 to 2021.
Acute mortality event in false pilchards Harengula clupeola after salinomycin and amprolium treatment for myxozoan (Enteromyxum leei) infection.
Dis Aquat Organ
January 2025
Mississippi Aquarium, Department of Veterinary Services, Gulfport, Mississippi 39502, USA.
This report documents complications in false pilchard Harengula clupeola and scad Decapterus macarellus associated with a salinomycin (60 mg kg-1) and amprolium (100 mg kg-1) gel feed treatment, along with prolonged temperature increase, for an Enteromyxum leei outbreak in a salt water, mixed species, public aquarium exhibit. Shortly after administration, a mass mortality event ensued where hundreds of false pilchards and a few scad died. Medicated gel feed was noted within the gastrointestinal tracts of all affected fish.
View Article and Find Full Text PDFAcclimation of Hairless Spontaneously Hypertensive Rat to Ambient Temperature Attenuates Hypertension-Induced Pro-Arrhythmic Downregulation of Cx43 in the Left Heart Ventricle of Males.
Biomolecules
November 2024
Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia.
Objectives: Due to poor treatment adherence and lifestyle-based interventions, chronic hypertension is a dominant risk factor predisposing individuals to heart failure and malignant arrhythmias. We investigated the impact of the postnatal acclimation of hairless SHR to ambient temperature that is, for them, below thermoneutrality, on the electrical coupling protein connexin-43 (Cx43) and pro-fibrotic markers in both heart ventricles of male and female hairless SHR rats compared to the wild SHR.
Methods: Some 6-month-acclimated male and female hairless SHR as well as age- and sex-matched wild SHR were included and compared with the non-hypertensive Wistar strain.
Effects of Extreme Humidity and Heat on Ventricular Arrhythmia Risk in Patients With Cardiac Devices.
JACC Adv
January 2025
Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Background: Climate change is increasing the frequency of high heat and high humidity days. Whether these conditions can trigger ventricular arrhythmias [ventricular tachycardia/ventricular fibrillation, VT/VF] in susceptible persons is unknown.
Objectives: The purpose of this study was to determine the relationship between warm-season weather conditions and risk of VT/VF in individuals with pacemakers and defibrillators.
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