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Molecular identification and genetic variability of equine and bovine ocular setariasis in india: molecular profiling by mitochondrial genes.
Mol Biol Rep
August 2024
Division of Parasitology, ICAR- Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Background: Ocular setariasis is an ectopic infection caused by a parasite under the genus Setaria. Adult worms belong to the Setariidae family and typically reside in the peritoneal cavity of ungulates. However, immature forms of these species may aberrantly migrate to the eyes of cattle, buffalo, goats, horses and several other hosts, leading to corneal opacity and blindness.
View Article and Find Full Text PDFDetection and characterization of vector-borne parasites and Wolbachia endosymbionts in greater one-horned rhinoceros (Rhinoceros unicornis) in Nepal.
Acta Trop
October 2024
Laboratory of Parasitology, Graduate School of Infectious Diseases, Faculty of Veterinary Medicine, Hokkaido University, Japan; Division of Parasitology, Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Japan. Electronic address:
Article Synopsis
- Vector-borne parasite infections are common in both domestic and wild animals, often asymptomatic but potentially fatal, particularly under stress.
- This study focused on the detection and characterization of such parasites in rescued greater one-horned rhinoceroses in Chitwan National Park, Nepal, using advanced molecular techniques on blood samples.
- Results revealed a 75% prevalence of Theileria bicornis, two new haplotypes, and the presence of Wolbachia and filarial nematodes, indicating a need for enhanced parasite surveillance and further research on wildlife diseases in the region.
extracellular replication of endobacteria.
Front Microbiol
July 2024
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Obligate intracellular endobacteria of the genus are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy with antibiotics are based on this important endosymbiont. Investigating , however, is impeded by the need for host cells.
View Article and Find Full Text PDFInfectivity of Plasmodium parasites to Aedes aegypti and Anopheles stephensi mosquitoes maintained on blood-free meals of SkitoSnack.
Parasit Vectors
July 2024
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Background: Aedes and Anopheles mosquitoes are responsible for tremendous global health burdens from their transmission of pathogens causing malaria, lymphatic filariasis, dengue, and yellow fever. Innovative vector control strategies will help to reduce the prevalence of these diseases. Mass rearing of mosquitoes for research and support of these strategies presently depends on meals of vertebrate blood, which is subject to acquisition, handling, and storage issues.
View Article and Find Full Text PDFComprehensive approach to in silico identification and in vitro validation of anti-filarial hit molecules targeting the dimer interface of thioredoxin peroxidase 1 in Wuchereria bancrofti: a progress in anti-filariasis drug development.
Mol Divers
July 2024
Department of Computational Sciences, Central University of Punjab, Bathinda, Punjab, 151401, India.
Lymphatic filariasis (LF) remains a significant health challenge for populations in developing countries. LF is a parasitic disease transmitted by mosquitoes, mainly caused by the filarial nematode, Wuchereria bancrofti, prevalent in tropical and subtropical regions. Since the present drugs develop complications, including adverse side effects, lack of specificity, and development of drug resistance, the present study focused on developing the potential anti-filariasis drugs targeting crucial proteins for the nematode life cycle.
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