AI Article Synopsis
- The study tested the effectiveness of cytostatic and anti-inflammatory drugs on a specific immune response in mice, known as cutaneous basophil hypersensitivity (CBH) induced by oxazolone.
- The drugs were administered at various times around sensitization and challenge, revealing that cytostatics primarily work during cell commitment, while corticosteroids target inflammation in that phase, and NSAIDs have variable effects.
- D-Penicillamine and levamisole showed similar suppressive effects in normal animals, indicating that the CBH model is useful for examining drug effects on T-cell related inflammation.
Article Abstract
The potency of cytostatic and anti-inflammatory drugs was tested on the oxazolone-induced cutaneous basophil hypersensitivity (CBH) in mice. The challenge reaction was performed early after sensitization in order to minimize B-cell expression; exudative and cellular infiltration was estimated 6 h, 24 h and 48 h after challenge. The potency of drugs was tested at three different periods of immunization: 2 days before or after sensitization or before challenge. Cytostatics act mainly when cells are being committed, a corticoid acts on inflammation linked to committed cells, NSAIDs show inconstant anti-inflammatory effects on this test. D-Penicillamine and levamisole act in the same depressive profile in normal animals. Thus the CBH model appears to be relevant in studying drug activities on inflammation linked to T-cell expression.
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| http://dx.doi.org/10.1007/BF01968124 | DOI Listing |
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