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A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model.
Elife
January 2025
Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima, Japan.
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establish a simple PEP risk score model (SuPER model: Support for PEP Reduction) that can be applied before ERCP.
View Article and Find Full Text PDFLocal tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model.
Am J Physiol Gastrointest Liver Physiol
February 2025
Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States.
This study aimed to determine if local injection of C-X-C motif chemokine ligand 12 (CXCL12) reduces sphincter fibrosis, restores sphincter muscle content, vascularization, and innervation, and recruits progenitor cells in a rabbit model of anal sphincter injury and incontinence. Adult female rabbits were assigned to three groups: uninjured/no treatment (control), injured/treated (treated), and injured/no treatment (untreated) ( = 4 each). Injured groups were anesthetized, and a section of external anal sphincter was removed at the 9 o'clock position.
View Article and Find Full Text PDFAGA Clinical Practice Update on Advances in Per-Oral Endoscopic Myotomy (POEM) and Remaining Questions-What We Have Learned in the Past Decade: Expert Review.
Gastroenterology
December 2024
Baylor Scott and White Center for Esophageal Diseases, Baylor University Medical Center, Dallas, Texas.
Description: This American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) aims to review the available evidence and provide expert advice regarding advances in per-oral endoscopic myotomy (POEM).
Methods: This CPU was commissioned and approved by the AGA Institute CPU Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPU Committee and external peer review through standard procedures of Gastroenterology. This review is framed around best practice advice points agreed upon by the authors, based on the current available evidence and expert opinion in this field.
Prediction for post-ERCP pancreatitis in non-elderly patients with common bile duct stones: a cross-sectional study at a major Chinese tertiary hospital (2015-2023).
BMC Med Inform Decis Mak
May 2024
Department of Biliary and Pancreatic Surgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, No. 17 Lujiang Road, Hefei, 230001, Anhui Province, China.
Background: Post-ERCP pancreatitis is one of the most common adverse events in ERCP-related procedures. The purpose of this study is to construct an online model to predict the risk of post-ERCP pancreatitis in non-elderly patients with common bile duct stones through screening of relevant clinical parameters.
Methods: A total of 919 cases were selected from 7154 cases from a major Chinese tertiary hospital.
Dilip's Transmucosal Internal Sphincterotomy: A Simplified Approach to Lateral Internal Sphincterotomy for Fissure in Ano.
Dis Colon Rectum
August 2024
Jabalpur Hospital and Research Centre, Jabalpur, Madhya Pradesh, India.
Article Synopsis
- Innovative Approach
- : Dilip's transmucosal internal sphincterotomy simplifies the traditional method of treating fissure in ano by minimizing the risk of external sphincter damage, making it a safer option for less experienced surgeons.
- Procedure Benefits
- : This technique involves less dissection and allows for better control over the internal sphincter, resulting in reduced postoperative pain and lower complication rates compared to conventional surgery.
- Positive Outcomes
- : In a study of 124 patients, the procedure had quick recovery times, low infection and incontinence rates, and a high healing rate, suggesting it’s an effective treatment method with few recurrences.
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