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Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder - A link and an influence of DHEA?
Indian J Psychiatry
December 2024
Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Background: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders.
Methods: To investigate the impact of cortisol levels on within-session habituation of distress - a measure of success of exposure therapy - in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention.
Adverse childhood experiences and diurnal cortisol pattern and heart rate variability in adults.
Psychoneuroendocrinology
January 2025
School of Sport, Exercise and Health Sciences, Loughborough University, United Kingdom.
Dysregulation of hypothalamic-pituitary-adrenal axis (HPA axis) and of the autonomic nervous system may link stress throughout the life course with poorer health. This study aims to investigate whether multiple adverse childhood experiences have a long-term impact on markers of these systems - cortisol secretion and heart rate variability - in adulthood. Data were from the Whitehall II cohort study.
View Article and Find Full Text PDF"Ontogenetic Scaling of the Primate Middle Ear".
Am J Primatol
January 2025
Anthropology Department, University of Florida, Gainesville, Florida, USA.
The study of primate auditory morphology is a significant area of interest for comparative anatomists, given the phylogenetic relationships that link primate hearing and the morphology of these auditory structures. Extensive literature addresses the form-to-function relationship of the auditory system (outer, middle, and inner ear) in primates and, by extension, provides insight into the auditory system of extinct primates and even modern humans. We add to this literature by describing the ontogenetic trajectory of the middle ear cavity and ossicular chain (malleus, incus, and stapes) due to their critical role in relaying auditory stimuli for interpretation.
View Article and Find Full Text PDFBmal1-mediated circadian MELK expression potentiates MELK inhibitor chronotherapy for esophageal cancer.
Mol Cancer Res
December 2024
Shenzhen University, shenzhen, China.
Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) is a significant global health issue, and this study explores the relationship between circadian rhythms and the Maternal embryonic leucine zipper kinase (MELK) in its progression.
- In both animal and human ESCC models, MELK was found to have a pronounced circadian expression, with levels significantly higher at specific times, suggesting a link to the body’s internal clock.
- The findings indicate that targeting MELK may provide a therapeutic strategy for ESCC, emphasizing the importance of timing in cancer treatments through chronotherapy.
The genetically programmed rhythmic alteration of diurnal gene expression in the aged leaves.
Front Plant Sci
November 2024
Department of New Biology, Daegu Gyeongbuk Institute of Science&Technology (DGIST), Daegu, Republic of Korea.
The circadian clock regulates the daily pattern of temporal gene expression. In Arabidopsis, aging is associated with a shortening of the endogenous period of circadian rhythms under circadian conditions. However, the functional link between the circadian clock and aging under diurnal conditions and its physiological relevance remain elusive.
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