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identification of silent primycin biosynthetic gene clusters within the family .
Heliyon
January 2025
Institute of Biology, Faculty of Sciences, University of Pécs, H-7624, Pécs, Hungary.
In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. Rare actinomycetes are a prolific source of structurally diverse secondary metabolites that exhibit remarkable clinical and industrial importance. Recently several excellent genome mining tools have been available for identifying biosynthetic gene clusters, however in cases of poor-quality sequences and inappropriate genome assembly, these tools are not always able to identify the corresponding gene clusters.
View Article and Find Full Text PDFStructural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability.
World J Microbiol Biotechnol
September 2020
Faculty of Sciences, Institute of Biology, University of Pécs, 7624, Pécs, Hungary.
Emerging and re-emerging microbial pathogens, together with their rapid evolution and adaptation against antibiotics, highlight the importance not only of screening for new antimicrobial agents, but also for deepening knowledge about existing antibiotics. Primycin is a large 36-membered non-polyene macrolide lactone exclusively produced by Saccharomonospora azurea. This study provides information about strain dependent primycin production ability in conjunction with the structural, functional and comparative genomic examinations.
View Article and Find Full Text PDFToxicology studies of primycin-sulphate using a three-dimensional (3D) in vitro human liver aggregate model.
Toxicol Lett
November 2017
Department of Pharmaceutical Biotechnology, School of Pharmacy, University of Pécs, 2 Rókus Str., H-7624 Pécs, Hungary; Szentágothai Research Center, University of Pécs, 20 Ifjúság Str., H-7624 Pécs, Hungary; Humeltis Ltd, 20 Ifjúság Str., Pécs, Hungary. Electronic address:
Primycin-sulphate is a highly effective compound against Gram (G) positive bacteria. It has a potentially synergistic effect with vancomycin and statins which makes primycin-sulphate a potentially very effective preparation. Primycin-sulphate is currently used exclusively in topical preparations.
View Article and Find Full Text PDFEffect of primycin on growth-arrested cultures and cell integrity of Staphylococcus aureus.
Acta Microbiol Immunol Hung
June 2017
2 Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary.
Bactericidal effect against non-dividing bacteria is a very advantageous, but rare characteristic among antimicrobial agents, mostly possessed by those affecting the cell membrane. These kinds of agents can kill bacterial cells without lysis. We assessed these characteristics on primycin, a topical anti-staphylococcal agent highly effective against prevalent multiresistant strains, as it also acts on the cell membrane.
View Article and Find Full Text PDFProteomic insight into the primycin fermentation process of Saccharomonospora azurea.
Acta Biol Hung
December 2016
Department of General and Environmental Microbiology, University of Pécs, Pécs , Hungary.
Saccharomonospora azurea SZMC 14600 is a member of the family Pseudonocardiaceae exclusively used for industrial scale production of primycin a large 36-membered non-polyene macrolide lactone antibiotic belonging to the polyketide class of natural products. Even though maximum antibiotic yield has been achieved by empirically optimized two-step fermentation process, little is known about the molecular components and mechanisms underlying the efficient antibiotic production. In order to identify differentially expressed proteins (DEPs) between the pre- and main-fermentation stages of primycin, comparative 2D-PAGE experiments were performed.
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