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Splenic Modulation of Plasmodium vivax Relapses and Hypnozoite Activation during the Second World War?
Am J Trop Med Hyg
November 2024
Australian Defence Force Malaria and Infectious Disease Institute, Enoggera, Australia.
Despite their colonial experience with tropical medicine, Allied (United States, United Kingdom, Australia, and India) Armies in the Indo-Pacific region were surprised by the large number of Plasmodium vivax infections in their soldiers during the Second World War. Even after the institution of effective chemoprophylaxis with quinacrine, multiple cycles of clinical relapses often occurred when months of medication was discontinued. Nearly monthly symptomatic relapses (>10) were not unusual and resulted in important manpower losses after each campaign.
View Article and Find Full Text PDFDose response effects of theacrine on cognitive performance and subsequent sleep.
Sci Rep
November 2024
School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.
Psychostimulants can be employed as a countermeasure to cognitive declines resulting from insufficient sleep. Although caffeine is the most consumed psychostimulant, consumption can cause adverse side-effects, including sleep disturbance. Therefore, there is interest in identifying alternative supplements that improve cognitive performance without compromising subsequent sleep.
View Article and Find Full Text PDFHepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling.
Life Sci
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:
Article Synopsis
- The study evaluated quinacrine, an FDA-approved drug, for its protective effects against hepatic encephalopathy (HE) in a rat model with bile duct ligation (BDL) and focused on the liver-brain communication through BMP2 signaling.
- Results indicated that BDL caused significant liver damage and cognitive deficits in rats, but quinacrine treatment improved liver function and cognitive abilities by restoring crucial signaling pathways.
- The findings suggest that quinacrine may offer potential benefits for treating HE by enhancing liver and brain health, highlighting the role of BMP2 signaling in this process.*
Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury.
Bull Exp Biol Med
June 2024
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
This study aimed to investigate the cardioprotective effect of quinacrine in an in vivo model of myocardial ischemia/reperfusion injury. A 30-min regional myocardial ischemia followed by a 2-h reperfusion was modeled in anesthetized Wistar rats. Starting at the last minute of ischemia and during the first 9 min of reperfusion the rats in the control (n=8) and experimental (n=9) groups were injected with 0.
View Article and Find Full Text PDFRepurposing antiplasmodial leads for cancer: Exploring the antiproliferative effects of N-cinnamoyl-aminoacridines.
Bioorg Med Chem Lett
October 2024
LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Portugal. Electronic address:
Drug repurposing and rescuing have been widely explored as cost-effective approaches to expand the portfolio of chemotherapeutic agents. Based on the reported antitumor properties of both trans-cinnamic acids and quinacrine, an antimalarial aminoacridine, we explored the antiproliferative properties of two series of N-cinnamoyl-aminoacridines recently identified as multi-stage antiplasmodial leads. The compounds were evaluated in vitro against three cancer cell lines (MKN-28, Huh-7, and HepG2), and human primary dermal fibroblasts.
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