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Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations , , and .
Front Physiol
December 2024
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Introduction: Adrenergic activation of protein kinase A (PKA) in cardiac muscle targets the sarcolemma, sarcoplasmic reticulum, and contractile apparatus to increase contractile force and heart rate. In the thin filaments of the contractile apparatus, cardiac troponin I (cTnI) Ser22 and Ser23 in the cardiac-specific N-terminal peptide (NcTnI: residues 1 to 32) are the targets for PKA phosphorylation. Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca associated with a higher rate of Ca dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy).
View Article and Find Full Text PDFNitazoxanide controls virus viability through its impact on membrane bioenergetics.
Sci Rep
December 2024
Institut Cochin, INSERM, CNRS, Université de Paris, 75014, Paris, France.
Viruses are dependent on cellular energy metabolism for their replication, and the drug nitazoxanide (Alinia) was shown to interfere with both processes. Nitazoxanide is an uncoupler of mitochondrial oxidative phosphorylation (OXPHOS). Our hypothesis was that mitochondrial uncoupling underlies the antiviral effects of nitazoxanide.
View Article and Find Full Text PDFAn alternative recommendation for design eccentricity by consideration of uncoupled frequency ratio.
Sci Rep
December 2024
Department of Civil Engineering, Mehmet Akif Ersoy University, Burdur, Turkey.
Civil structures are prone to dynamic loadings such as strong winds or ground excitations where torsion becomes an ongoing issue. This arises from a lack of coincidence of the center of mass (CM) and rigidity (CR), known as eccentricity. Seismic design codes often introduce two types of eccentricity: inherent (geometric) and accidental.
View Article and Find Full Text PDFCollective Interactions of Quantum-Confined Excitons in Halide Perovskite Nanocrystal Superlattices.
ACS Nano
December 2024
Department of Materials Science and Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Collective optical properties can emerge from an ordered ensemble of emitters due to interactions between the individual units. Superlattices of halide perovskite nanocrystals exhibit collective light emission, influenced by dipole-dipole interactions between simultaneously excited nanocrystals. This coupling changes both the emission energy and rate compared to the emission of uncoupled nanocrystals.
View Article and Find Full Text PDFDivergent selection for basal metabolic rate in mice affects the abundance of UCP1 protein: implications for translational studies.
J Physiol
December 2024
Faculty of Biology, University of Białystok, Białystok, Poland.
Low basal metabolic rate (BMR) is a risk factor for obesity, whereas elevation of non-shivering thermogenesis (NST) is a promising means to combat obesity. Because heat generated by NST covers thermogenic needs not fulfilled by BMR, one can expect the presence of a negative relationship between both parameters. Understanding of the mechanisms underlying this relationship is therefore important for interpretation of the results of translational experiments and the development of anti-obesity treatments.
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