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Probing the orientation and membrane permeation of rhodamine voltage reporters through molecular simulations and free energy calculations.
J Mater Chem B
January 2025
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Article Synopsis
- The transmembrane potential is crucial for cellular functions like signaling and energy production, with Rhodamine voltage reporters (RhoVRs) serving as small, non-invasive sensors that can detect voltage changes, especially in mitochondria.
- Extensive simulations and free-energy calculations revealed that the orientation of RhoVRs relative to membranes, influenced by their polarized functional groups, significantly impacts their voltage sensitivity and localization within cells.
- The study's findings on the relationship between the chemical structure of RhoVRs and their membrane behavior offer valuable insights for designing fluorescent dyes that better detect voltage changes.
A Novel Substituted Benzo[]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent.
J Med Chem
December 2024
Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61 200 Brno, Czech Republic.
Herein, we describe and investigate biological activity of three octahedral ruthenium(II) complexes of the type [Ru(CN)(phen)], -, containing a π-expansive cyclometalating substituted benzo[]quinoxaline ligand (CN ligand) (phen = 1,10-phenanthroline). Compounds - in cervical, melanoma, and colon human cancer cells exhibit high phototoxicity after irradiation with light (particularly blue), with the phototoxicity index reaching 100 for the complex in most sensitive HCT116 cells. accumulates in the cellular membranes.
View Article and Find Full Text PDFAdvances and challenges in dynamic photo-induced force microscopy.
Discov Nano
November 2024
Material Property Metrology Group, Korea Research Institute of Standards and Science (KRISS), Daejeon, 34113, Republic of Korea.
Article Synopsis
- Photo-induced force microscopy (PiFM) is a high-resolution imaging technique that utilizes photo-induced forces to enhance tip movement, allowing for detailed nanoscale spectroscopic imaging.
- This review covers the complexities of PiFM, including the influences of both local dipole interactions and thermal expansion, and distinguishes between far-field and near-field effects.
- The article serves as a comprehensive guide for beginners, combining theoretical insights with practical examples that span from basic concepts to more advanced topics in the field.
Photoclick and Release for Spatiotemporally Localized Theranostics of Single Cells via In Situ Generation of 1,3-Diaryl-1H-benzo[f]indazole-4,9-dione.
Angew Chem Int Ed Engl
November 2024
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
Bioorthogonal click-release chemistry is a cutting-edge tool for exploring and manipulating biomolecule functions in native biological systems. However, it is challenging to achieve the precise regulation or therapy of individual cells via click-release strategies driven by proximity and thermodynamics. Herein, we propose a novel photoclick-release approach based on a photo-induced cycloaddition between 4,4'-bis(N-arylsydnone) or C-bithienyl-diarylsydnone and 2-arylamino-naphthoquinone via irradiation with 405 or 485 nm light.
View Article and Find Full Text PDFPhotoinduced Isomerization of [N] in a Bimetallic Lutetium Complex.
J Am Chem Soc
November 2024
MPA-11 Materials Synthesis and Integrated Devices, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
The first lanthanide dinitrogen photoswitch [(CMeH)(THF)Lu](μ-η:η-N), , is reported. is a unique example of controlled isomerization between side-on and end-on coordination modes of [N] in a bimetallic lutetium dinitrogen complex that results in photochromism. Near-infrared light (NIR) was used to promote this effect, as evidenced by single X-ray diffraction (XRD) connectivity and Raman data, generating the [N] end-on bound isomer, [(CMeH)(THF)Lu](μ-η:η-N), .
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