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A self-elastic chitosan sponge reinforced with lauric acid-modified quaternized chitosan and attapulgite to treat noncompressible hemorrhage and facilitate wound healing.
Carbohydr Polym
March 2025
Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address:
The development of self-elastic sponges with enhanced hemostatic and antibacterial properties to treat noncompressible hemorrhage and facilitate wound healing remains challenging. Herein, we prepared a chitosan sponge reinforced with lauric acid-modified quaternized chitosan (LQC) and attapulgite, features a porous structure, high self-elasticity, and rapid shape recovery. The incorporation of LQC conferred the sponge with an enhanced capacity to promote the adhesion, aggregation, and activation of blood cells, and resistance to infection by Staphylococcus aureus, Escherichia coli, and Methicillin-resistant Staphylococcus aureus; the incorporation of attapulgite enhanced the hydrophilicity and mechanical strength of the sponge, and its ability to activate the intrinsic and extrinsic coagulation pathways.
View Article and Find Full Text PDFYttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.
ACS Omega
December 2024
Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K.
Article Synopsis
- The study develops high yttrium-content phosphate-based glass-ceramic microspheres for use in bone cancer radiotherapy, showcasing their production through flame spheroidization and resulting in a narrow size distribution (45-125 μm).
- Energy dispersive X-ray (EDX) analysis indicates an increase in yttrium content in the microspheres with higher yttrium oxide ratios, while showing a uniform distribution and a decrease in phosphate, calcium, and magnesium levels.
- In vitro tests reveal that these microspheres exhibit good cytocompatibility, with enhanced cellular responses compared to earlier P40 glass microspheres, highlighting their potential as biomaterials for cancer treatment.
How chloride salt mixtures affect the final gel properties of low-sodium myofibrillar protein: Underlining the perspective of gelation process.
Meat Sci
March 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address:
This study aimed to investigate the performance differences of low-sodium myofibrillar protein (MP) gels substituted by different chloride salt mixtures from the perspective of gelation process. The results revealed that low-sodium MP substituted by KCl/CaCl exhibited higher turbidity and particle size at 40 % substitution, and formed protein aggregates earlier at 53 °C. During the gelation process, KCl/CaCl increased the extent of cross-linking as the substitution level increased from 10 % to 40 %, which was prone to forming final gels with poor palatability.
View Article and Find Full Text PDFThe N-terminal polypeptide of a new shell matrix protein hicraqin accelerates the rate of calcium carbonate deposition.
Protein Expr Purif
March 2025
Department of Biotechnology and Biomedicine, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, 314000, China; Taizhou Innovation Center, Yangtze Delta Region Institute of Tsinghua University, Zhejiang, 318000, China; Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, 705 Yatai Road, Jiaxing, 314006, China. Electronic address:
Matrix proteins play important roles in shell formation by regulating the assembly of organic matrix and minerals. Here, we obtained a new matrix protein (hicraqin) from Hyriopsis cumingii. The amino acid sequence of hicraqin contains multiple aggregated (Gly)n (n > 2) residues, a feature unique to silk-like matrix proteins.
View Article and Find Full Text PDFMechanism of Metal Complexes in Alzheimer's Disease.
Int J Mol Sci
November 2024
Guangdong Key Laboratory for Genome Stability & Disease Prevention, International Cancer Center, Department of Pharmacology, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
Alzheimer's disease (AD) is a kind of neurodegenerative diseases characterized by beta-amyloid deposition and neurofibrillary tangles and is also the main cause of dementia. According to statistics, the incidence of AD is constantly increasing, bringing a great burden to individuals and society. Nonetheless, there is no cure for AD, and the available drugs are very limited apart from cholinesterase inhibitors and N-Methyl-D-aspartic acid (NMDA) antagonists, which merely alleviate symptoms without delaying the progression of the disease.
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