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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial.
J Med Internet Res
January 2025
School of Public Health, University of Haifa, Haifa, Israel.
Background: Increasing life expectancy has led to a rise in nursing home admissions, a context in which older adults often experience chronic physical and mental health conditions, chronic pain, and reduced well-being. Nonpharmacological approaches are especially important for managing older adults' chronic pain, mental health conditions (such as anxiety and depression), and overall well-being, including sensory stimulation (SS) and therapist support (TS). However, the combined effects of SS and TS have not been investigated.
View Article and Find Full Text PDFEfficacy and Renal Safety of Protocol-based 11.7% Hypertonic Saline Infusion Compared with 20% Mannitol in Patients with Elevated Intracranial Pressure: A Study Protocol for a Randomized Clinical Trial.
Electrolyte Blood Press
December 2024
Department of Internal Medicine, College of Medicine, Dankook University, Republic of Korea.
Background: Elevated intracranial pressure (ICP) is a potentially life-threatening condition requiring prompt intervention. While both mannitol and hypertonic saline (HTS) are commonly used hyperosmotic agents for treating elevated ICP, there is insufficient evidence comparing their renal safety profiles and overall effectiveness. This study protocol outlines a pragmatic randomized trial to compare protocol-based 11.
View Article and Find Full Text PDFOutcomes for smokers who develop melanoma: a systematic review and meta-analysis.
EClinicalMedicine
November 2024
Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Background: There is compelling evidence that the incidence of melanoma in cigarette smokers is substantially lower than in non-smokers. However, the risks of both recurrence and death appear to be higher in smokers if melanoma does develop. The magnitude of these increased risks is poorly documented.
View Article and Find Full Text PDFRelative Efficacy of Internet-based and Face-to-face Behavioural Parent Training for Parents of Children with Attention-deficit/ hyperactivity disorder: a Non-randomised Controlled Trial.
Neuropsychopharmacol Hung
December 2024
Heim Pál National Paediatric Institute, Centre of Mental Health, Budapest, Hungary.
Article Synopsis
- Behavioural Parent Training (BPT) is an effective intervention for ADHD in children, and this study compares face-to-face training with an online version to see which format is more effective for parents.
- The study involved 90 parents, with many preferring online training; however, a significant dropout rate left only 60 parents for the online analysis.
- Results showed that face-to-face participants were more likely to implement certain parenting strategies, specifically the reward system, while no major differences were found in how parental ADHD symptoms influenced training format choice.
Relative efficacy of systemic treatments for patients with relapsed/refractory chronic lymphocytic leukemia: a network meta-analysis according to 17p deletion/TP53 mutations.
Blood Res
January 2025
Department of Hematology-Oncology, Inha University College of Medicine and Hospital, 7-206 Third Street, Shinheung-Dong Jung-Gu, Incheon, Republic of Korea.
Purpose: This network meta-analysis aimed to evaluate the relative efficacy of systemic treatments in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL), focusing on key genetic mutations, specifically the 17p deletion and TP53 mutations.
Methods: We conducted a systematic literature review to identify all publicly available randomized controlled trials (RCTs) using PubMed, EMBASE, the Cochrane database, and meeting abstracts published through December 2023. A Bayesian network meta-analysis was performed to estimate the hazard ratios (HRs) for progression-free survival (PFS) with 95% confidence intervals (CIs) and to determine the ranking of the included regimens.
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