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Efficacy and safety of risankizumab for the treatment of patients with plaque type psoriasis.
Ital J Dermatol Venerol
January 2025
Department of Dermatology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (ROC) -
Risankizumab (Skyrizi, Abbvie, North Chicago, IL, USA) is a humanized immunoglobulin (Ig) G1 monoclonal antibody targeting the p19 subunit of IL-23, thereby inhibiting IL-23-dependent releasing of proinflammatory cytokines in plaque psoriasis. Risankizumab is licensed is most countries for the treatment of patients with moderate-to-severe plaque psoriasis, and in Japan for generalized pustular psoriasis, erythrodermic psoriasis and palmoplantar pustulosis. Risankizumab showed higher efficacy and favorable safety profiles in patients with moderate-to-severe plaque psoriasis, compared with adalimumab, secukinumab and ustekinumab in several randomized controlled phase 3 pivotal studies and among real-life data in large retrospective studies.
View Article and Find Full Text PDFStrategies for Diagnosing and Treating Disseminated Methicillin-Sensitive Staphylococcus aureus Infections: Insights From a Pustular Eruption.
Cureus
August 2024
Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
Article Synopsis
- A 63-year-old man with a renal transplant and lymphoma undergoing chemotherapy (R-CHOP) developed fever and a widespread pustular rash, which were linked to septicemia.
- After ruling out other conditions, tests confirmed a methicillin-sensitive Staphylococcus aureus (MSSA) infection, primarily from his infected venous access port.
- Treatment involved removing the port and using a combination of antibiotics, leading to improvement, highlighting the significance of proper diagnosis and management of similar infections in immunocompromised patients.
Pustular mycosis fungoides has a poor outcome: a multicentric clinicopathological and molecular case series.
Br J Dermatol
December 2024
Department of Pathology, Henri Mondor University Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France.
Background: Mycosis fungoides (MF) usually has an indolent course. However, some patients develop more aggressive disease and few prognostic parameters have been identified. Isolated cases of pustular MF (pMF) suggest an unfavourable prognosis.
View Article and Find Full Text PDFEffect of smoking cessation on psoriasis vulgaris, palmoplantar pustulosis and generalized pustular psoriasis.
Br J Dermatol
July 2024
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: Smoking is a known risk factor for psoriasis; however, the impact of smoking cessation on psoriasis has seldom been evaluated.
Objectives: We aimed to examine the effects of smoking cessation on the development of psoriasis vulgaris (PsV), palmoplantar pustulosis (PPP) and generalized pustular psoriasis (GPP).
Methods: Using the Korean National Health Insurance Service database, we retrospectively compiled a cohort of 5 784 973 participants without psoriasis, analysed their changes in smoking status from 2004 to 2007 and followed up new cases of psoriasis until 2021.
Epidemiology, Characteristics of Disease, and Unmet Needs of Patients with Generalized Pustular Psoriasis: A Large Italian Delphi Consensus.
Dermatology
June 2024
Section of Dermatology and Venereology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Article Synopsis
- Generalized pustular psoriasis (GPP) is a rare and severe skin condition that can have serious systemic effects, with limited research data, particularly in Europe, prompting a study focused on the Italian context.
- The study utilized an iterative eDelphi method involving 35 Italian experts, including dermatologists and patient representatives, to explore various aspects of GPP such as epidemiology, disease characteristics, diagnosis, treatment, and patient experiences.
- The findings indicated strong consensus on issues like GPP's incidence and recommended diagnostic criteria, but revealed a lack of agreement on treatment approaches for different phases of the condition.
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