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Focal mandibular osteonecrosis following intraosseous anesthesia: A case report.
Int J Surg Case Rep
January 2025
Department of Oral and Maxillofacial Surgery, AZORG Hospital, Aalst, Belgium. Electronic address:
Introduction And Importance: Intraosseous anesthesia (IOA), an important technique in dental anesthesia, delivers anesthetic directly into the bone, enhancing patient comfort and minimizing side effects. Despite advantages, several disadvantages are known such as injection discomfort, root damage, mechanical obstructions and needle fractures. This report highlights a rare yet significant complication of focal mandibular osteonecrosis following IOA.
View Article and Find Full Text PDFDeciphering the mechanism for encapsulation of MOF (Fe-glutaric acid) onto Se/SnO embedded CMC for effective aqueous sequestration of pharmaceutical pollutant via adsorption.
Environ Monit Assess
January 2025
Department of Botany, Bacha Khan University, Charsadda, Charsadda, 24420, Khyber Pakhtunkhwa, Pakistan.
Wastewater is commonly contaminated with many pharmaceutical pollutants, so an efficient purification method is required for their removal from wastewater. In this regard, an innovative tertiary Se/SnO@CMC/Fe-GA nanocomposite was synthesized through encapsulation of metal organic frameworks (Fe-glutaric acid) onto Se/SnO-embedded-sodium carboxy methyl cellulose matrix to thoroughly evaluate its effectiveness for adsorption of levofloxacin drug from wastewater. The prepared Se/SnO@CMC/Fe-GA nanocomposite was analyzed via UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermo gravimetric analysis (TGA), energy dispersive X-ray (EDX), and X-ray diffraction (XRD) to valuate optical property, size, morphology, thermal stability, and chemical composition.
View Article and Find Full Text PDFMitoStores: stress-induced aggregation of mitochondrial proteins.
Biol Chem
January 2025
Cell Biology, 26562 RPTU University of Kaiserslautern, Erwin-Schrödinger-Strasse 13, D-67663 Kaiserslautern, Germany.
Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into mitochondria. If the rate of protein synthesis exceeds the capacity of the mitochondrial import machinery, precursor proteins can transiently accumulate in the cytosol. The cytosolic accumulation of mitochondrial precursors jeopardizes cellular protein homeostasis (proteostasis) and can be the cause of diseases.
View Article and Find Full Text PDFActivation and memory of the heatshock response is mediated by Prion-like domains of sensory HSFs in Arabidopsis.
Mol Plant
January 2025
Leibniz Institut für Gemüse und Zierpflanzenbau (IGZ) e.V., Großbeeren, Germany; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany. Electronic address:
Plants are able to sense and remember heat stress. An initial priming heat stress enables plants to acclimate so that they are able to survive a subsequent higher temperature. The heatshock transcription factors (HSFs) play a crucial role in this process, but the mechanisms by which plants sense heat stress are not well understood.
View Article and Find Full Text PDFMechanism of small heat shock protein client sequestration and induced polydispersity.
bioRxiv
December 2024
Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland OR 97239, U.S.A.
Small heat shock proteins (sHSPs) act as first responders during cellular stress by recognizing and sequestering destabilized proteins (clients), preventing their aggregation and facilitating downstream refolding or degradation. This chaperone function is critically important to proteostasis, conserved across all kingdoms of life, and associated with various protein misfolding diseases in humans. Mechanistic insights into how sHSPs sequester destabilized clients have been limited due to the extreme molecular plasticity and client-induced polydispersity of sHSP/client complexes.
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