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Altered Nigral Amide Proton Transfer Imaging Signal Concordant With Motor Asymmetry in Parkinson's Disease: A Multipool CEST MRI Study.
NMR Biomed
February 2025
Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Asymmetry is a natural characteristic of Parkinson's disease (PD), which can be used to distinguish PD from atypical parkinsonism. Chemical exchange saturation transfer (CEST) has demonstrated value in reflecting the subtle changes related to neuron loss and abnormal protein accumulation in PD but has not been used to investigate asymmetry in PD. This study aimed to examine asymmetrical changes in the mesencephalic nucleus of PD patients with motor asymmetry using four-pool CEST analysis and to explore the relationship between imaging asymmetry and motor asymmetry.
View Article and Find Full Text PDFAcute Ischemic Stroke Presenting as Hemiparkinsonism: A Case Report.
Neurohospitalist
October 2024
Department of Neuroradiology, Neurosurgical Teaching Hospital, Baghdad, Iraq.
Parkinsonism, commonly associated with Parkinson disease (PD), can also arise from other neurodegenerative disorders or non-neurodegenerative causes such as vascular parkinsonism (VP). This case highlights the acute onset of VP following a stroke, contributing to the understanding of VP's varied presentations and the challenges in its diagnosis. A 54-year-old male with a history of cerebrovascular disease presented with behavioral changes and reduced activity, initially raising the suspicion of a central nervous system infection.
View Article and Find Full Text PDFDynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation.
eNeurologicalSci
December 2024
Department of Neuropathology (Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Article Synopsis
- A 72-year-old man experienced a 6-month decline in voluntary speech marked by sparse speech and decreased word fluency, while other language abilities remained intact, indicating dynamic aphasia.
- Brain MRI showed left-sided white matter volume reduction in the frontal lobe, specifically affecting areas linked to speech production, and the patient's condition worsened over two years leading to complete mutism and death from aspiration pneumonia.
- The neuropathological diagnosis was corticobasal degeneration (CBD), suggesting that early signs of CBD may manifest as dynamic aphasia, potentially due to early involvement of certain brain pathways.
Neuropathologic findings in a patient with hemiparkinsonism and hemiatrophy syndrome.
Neuropathology
December 2024
Department of Neurology, Kansai Medical University, Osaka, Japan.
The first postmortem neuropathological findings of a hemiparkinsonism and hemiatrophy (HPHA) patient are presented. A 50-year-old man developed resting tremors affecting the right hand and leg, followed by mild clumsiness of the right hand. On examination, he exhibited muscle atrophy of the right leg extremity, accompanied by right-sided parkinsonism.
View Article and Find Full Text PDFBackground: Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD) points to a CNS response that could be targeted by therapeutic approaches, but recovery of striatal dopamine (DA) or tyrosine hydroxylase (TH) has been inconsistent in rodent studies.
Objective: To increase translation of AE, 3 components were implemented into AE design to determine if recovery of established motor impairment, concomitant with >80% striatal DA and TH loss, was possible. We also evaluated if serum levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP), blood-based biomarkers of disease severity in human PD, were affected.
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