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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients.
Pharmaceutics
December 2024
PerMed Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
Background: Salbutamol, a short-acting β-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes. Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient.
View Article and Find Full Text PDFA Low-Power General Matrix Multiplication Accelerator with Sparse Weight-and-Output Stationary Dataflow.
Micromachines (Basel)
January 2025
Research Center for Novel Computing Sensing and Intelligent Processing, Zhejiang Lab, Hangzhou 311100, China.
General matrix multiplication (GEMM) in machine learning involves massive computation and data movement, which restricts its deployment on resource-constrained devices. Although data reuse can reduce data movement during GEMM processing, current approaches fail to fully exploit its potential. This work introduces a sparse GEMM accelerator with a weight-and-output stationary (WOS) dataflow and a distributed buffer architecture.
View Article and Find Full Text PDFGPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues.
Arthritis Res Ther
January 2025
Xin'an Medicine Research Center, the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), No 2, West Zheshan Road, Wuhu, Anhui, 241000, China.
Background: Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes.
Methods: Fresh RA patients' whole blood was transfused into NOD-SCID mice.
The relationships between photochemical reflectance index (PRI) and photosynthetic status in radish species differing in salinity tolerance.
J Plant Res
January 2025
Graduate School of Life Sciences, Tohoku University, Aoba, Sendai, 980-8578, Japan.
Since photosynthesis is highly sensitive to salinity stress, remote sensing of photosynthetic status is useful for detecting salinity stress during the selection and breeding of salinity-tolerant plants. To do so, photochemical reflectance index (PRI) is a potential measure to detect conversion of the xanthophyll cycle in photosystem II. Raphanus sativus var.
View Article and Find Full Text PDFThe Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice.
Vaccines (Basel)
January 2025
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Background/objectives: COVID-19 vaccines effectively prevent severe disease, but unequal distribution, especially in low- and middle-income countries, has led to vaccine-resistant strains. This highlights the urgent need for alternative vaccine platforms that are safe, thermostable, and easy to distribute. This study evaluates the immunogenicity, stability, and scalability of a dissolved microneedle array patch (MAP) delivering the rS1RS09 subunit vaccine, comprising the SARS-CoV-2 S1 monomer and RS09, a TLR-4 agonist peptide.
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