In this paper, we report the first observation of Hb G Coushatta (beta 22 (B4) Glu leads to Ala) in North Africa. An homozygous case was discovered and studied. The structural abnormality was characterized by using S. aureus protease. The analytical methods capable of distinguishing these hemoglobins from D Punjab, D Ouled Rabah and D Iran which have similar hemoglobin electrophoretic mobilities will be discussed.
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