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Z-Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis.
Immunol Rev
January 2025
Department of Biochemistry, Division of Biological Sciences, Indian Institute of Science, Bengaluru, Karnataka, India.
Z-nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z-conformation. Upon Z-nucleic acid sensing, ZBP1 triggers innate immune activation, inflammation, and programmed cell death during viral infections, mice development, and inflammation-associated diseases. The Zα domains of ZBP1 sense Z-nucleic acids and promote RIP-homotypic interaction motif (RHIM)-dependent signaling complex assembly to mount cell death and inflammation.
View Article and Find Full Text PDFSemi-standardized evaluation of extraprostatic extension and seminal vesicle invasion with [F]PSMA-1007 PET/CT: a comparison to MRI using histopathology as reference.
EJNMMI Rep
January 2025
Department of Translational Medicine, Lund University, Lund, Sweden.
Background: Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity in methods and results.
View Article and Find Full Text PDFZinner Syndrome in a Young Male: A Case Report and Review of the Literature.
Cureus
December 2024
Radiodiagnosis, MNR Medical College and Hospital, Sangareddy, IND.
Zinner syndrome is an extremely uncommon congenital anomaly of the male urogenital tract. It is attributed to an embryological anomaly that arises in the distal segment of the mesonephric or Wolffian duct. It is the inadequate migration of the ureteric bud that contributes to the failure of differentiation of the metanephric blastema, which ultimately results in ipsilateral renal agenesis and atresia of the ejaculatory duct.
View Article and Find Full Text PDFMetabolomic profile and its association with the diagnosis of prostate cancer: a systematic review.
J Cancer Res Clin Oncol
December 2024
Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Calle 4 B # 36-00, Cali, Colombia.
Article Synopsis
- The study aimed to explore how a specific metabolomic profile can help diagnose localized prostate cancer by examining various biological samples.
- Researchers analyzed a total of 1248 studies, narrowing down to 14 case-control studies that primarily focused on serum metabolite analysis, revealing significant associations with certain metabolites.
- The findings indicated that disruptions in the metabolism of fatty acids, amino acids, nucleotides, and steroid hormones are linked to localized prostate cancer, with notable increases in amino acids like glutamate and aspartic acid, and decreases in glycine and serine.
Clinical assessment of urinary prostate cancer antigen 3 in Chinese population: a large-scale, prospective and multicenter study.
World J Surg Oncol
December 2024
Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: To assess the clinical utility of PCA3 in the diagnostic accuracy, the correlation between PCA3 and biopsy or pathological characteristics and the performance of PCA3 to reduce the unnecessary biopsies in Chinese population.
Methods: A prospective study including patients with indication of prostate biopsies from 4 centers was conducted. All patients underwent PCA3 urine tests and prostate biopsies.
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