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Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review.
Int J Environ Res Public Health
February 2021
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
Article Synopsis
- Increasing environmental contamination from toxic compounds, particularly endocrine disrupting chemicals (EDCs), is a significant factor in reproductive defects affecting both males and females.
- EDCs influence reproductive health primarily by interacting with estrogen and androgen receptors, which are crucial for the development of reproductive systems and characteristics.
- The review examines various studies over the past decade to elucidate how EDCs, through binding to receptors and triggering different signals, can disrupt the endocrine system, leading to infertility through mechanisms like DNA damage and alterations in gene expression.
Phosphorylation of H2AX histone as indirect evidence for double-stranded DNA breaks related to the exchange of nuclear proteins and chromatin remodeling in Chara vulgaris spermiogenesis.
Protoplasma
November 2008
Department of Cytophysiology, University of Łódź, Łódź, Poland.
Phosphorylation of H2AX histone results not only from DNA damage (caused by ionizing radiation, UV or chemical substances, e.g. hydroxyurea), but also regularly takes place during spermiogenesis, enabling correct chromatin remodeling.
View Article and Find Full Text PDF[On the ontogenetic origin of human beings: the scientific solution].
Rev Med Chil
January 2007
Programa de Genética Humana (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Every living being is the result of a genome-environment interaction. Neither human oocytes nor spermatozoids have human functional genomes, but the zygote that they constitute may have a human functional genome and other functional genomes such as those of the hydatidiform mole, polyploids, and non-human living beings. When the zygotic human functional genome is integrated and activated, the biotic humanity is acquired.
View Article and Find Full Text PDFCytochemical studies on histone-type and protamine-type proteins during spermiogenesis in Chara vulgaris and Chara tomentosa.
Folia Histochem Cytobiol
January 2003
Department of Cytophysiology, University of Lódź, Poland.
Comparative studies concerning detection of histone-type and protamine-type proteins were carried out on Chara species (C. vulgaris, C. tomentosa).
View Article and Find Full Text PDF[Localization of proteins, specifically binding highly-repetitive sequences of DNA in human spermatozoids].
Tsitologiia
October 2001
St. Petersburg State University, Institute of Cytology RAS, St. Petersburg.
Immunoblot revealed in spermatozoa alpha-satellite (sat) DNA-specific centromere protein B (CENP-B) and p70 (Enukashvily et al., 2000), a membrane telomere binding protein (MTBP/TRF2) (Podgornaya et al., 2000), and Alu-binding protein p68 (Lukyanov et al.
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