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Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening.
Sci Rep
January 2025
Molecular Biology and Stem Cell Research Lab, Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science & Technology, Chennai, Tamilnadu, India.
Model organisms are vital for biomedical research and drug testing but face high costs, complexity, and ethical issues. While newer techniques like organoids and assembloids have shown improvements, they still remain inadequate in addressing all research needs. In this study, we present a new method for maintaining the prostate gland of the earthworm, Eudrilus eugeniae ex vivo and examine its potential for regeneration and drug screening.
View Article and Find Full Text PDFDeep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues.
Nat Commun
January 2025
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06536, USA.
To regain infectivity, Trypanosoma brucei, the pathogen causing Human and Animal African trypanosomiasis, undergoes a complex developmental program within the tsetse fly known as metacyclogenesis. RNA-binding protein 6 (RBP6) is a potent orchestrator of this process, however, an understanding of its functionally important domains and their mutational constraints is lacking. Here, we perform deep mutational scanning of the entire RBP6 primary structure.
View Article and Find Full Text PDFFish oil-loaded silver carp scale gelatin-stabilized emulsions with vitamins for the delivery of curcumin.
NPJ Sci Food
January 2025
Medical Food Laboratory, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
The encapsulation of curcumin in the emulsions has attracted much attention in functional food development. Herein, the fish oil-loaded silver carp scale gelatin-stabilized emulsions with vitamins were explored for the delivery of curcumin. The curcumin encapsulation had no obvious effect on the formation, storage stability, lipid oxidation, and in vitro droplet digestion behaviors of the emulsions.
View Article and Find Full Text PDFTranscellular regulation of ETI-induced cell death.
Trends Plant Sci
January 2025
State Key Laboratory of Wheat Improvement, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China; Shandong Engineering Research Center of Plant-Microbial Restoration for Saline-Alkali Land, Shandong Agricultural University, Tai'an, 271018, China. Electronic address:
To address the persistent challenge of cell death spread and limitation during effector-triggered immunity (ETI), we propose a 'concentric circle' model. This model outlines a regulatory framework, integrating multiple cells and diverse signaling molecules, including salicylic acid (SA), jasmonic acid (JA), and Ca. By accounting for the varying concentrations and spatiotemporal distributions of these molecules, our model aims for precision in immune defense and regulated cell death.
View Article and Find Full Text PDFImmobilization of biofunctional molecule with potential osteoinductive efficacy on titanium implant for promoting early-stage osseointegration.
J Craniomaxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa 920-0293, Japan.
In the present study, porcine-derived collagen type I was covalently immobilized on the surface of titanium (Ti) implants via carboxyl groups introduced by bonded p-vinylbenzoic acid to investigate its in vitro biocompatibility with gingival stem cells and in vivo bone regeneration behavior in the edentulous ridges of Lanyu small-ear pigs at weeks 2 and 6 (short-term effectiveness) through micro-computed tomography and histological analysis. Analytical results found that gingival stem cells showed effective adhesion and spreading on these collagen-immobilized implant surfaces. After 2 and 6 weeks of healing, significant differences in Hounsfield units were observed among the control (week 2 (674.
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