287-290. The functioning of erythrocytes was studied by determination of the activity of the pentose phosphate pathway in 431 individuals - 221 uranium miners, 42 employees of a uranium ore trimming station (30 of whom were exposed), 36 former uranium miners, 32 coal miners, and 100 persons not working in mines and with no previous exposure. In the groups exposed to long-term occupational radiation, the activity of the pentose phosphate cycle was found to be enhanced. This finding was interpreted as evidence for a change in the functional state of the erythrocytes in exposed persons due to the effects of radiation on the genesis of red cells in the bone marrow.
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http://dx.doi.org/10.1136/oem.27.3.287 | DOI Listing |
Radiat Res
January 2025
Federal Office for Radiation Protection, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
Lifetime risk estimates play a key role in many areas of radiation research. Here, the focus is on the lifetime excess absolute risk (LEAR) for dying from lung cancer due to occupational radon exposure based on uranium miners cohort studies. The major components in estimating LEAR were systematically varied to investigate the variability and uncertainties of results.
View Article and Find Full Text PDFProbl Radiac Med Radiobiol
December 2024
State Institution «O.M. Marzіeiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine», 50 Hetman Pavlo Polubotok Str., Kyiv, 02094, Ukraine.
Objective: assessment of probable exposure levels from radon and NORM in workplaces within the context of justi fying radiation protection plans in an existing exposure situation.
Materials And Methods: Materials regarding the assessment of naturally occurring radioactive material (NORM) con tent in tailing from mining and processing industries in Ukraine and assessments of contamination levels of industri al sites of oil and gas enterprises were used for estimating the probable range of effective doses (ED) of workers fromNORM at industrial enterprises. These materials were obtained as a result of research conducted by specialists from theRadiation Protection Laboratory of the State Institution «O.
Int Arch Occup Environ Health
November 2024
PSE-SANTE/SESANE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-Aux-Roses, France.
Objective: A recent update of the French cohort of uranium miners added seven years of follow-up data. We use these new data to look for new possible radon-related increased risks and refine the estimation of the potential association between cumulative radon exposure and four cancer sites: lung cancer, kidney cancer, brain and central nervous system (CNS) cancer and leukemia (excluding chronic lymphocytic leukemia, which is not radiation-induced).
Methods: Several parametric survival models are proposed, fitted and compared under the Bayesian paradigm, to perform new and original exposure-risk analyses.
Am J Epidemiol
August 2024
Field Research Branch, Division of Field studies and Engineering, National institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (DHHS), Cincinnati, Ohio, USA.
Radon is a known cause of lung cancer. Protective standards for radon exposure are derived largely from studies of working populations that are prone to healthy worker survivor bias. This bias can lead to under-protection of workers and is a key barrier to understanding health effects of many exposures.
View Article and Find Full Text PDFRadiat Environ Biophys
March 2024
Federal Office for Radiation Protection (BfS), Munich (Neuherberg), Germany.
The Pooled Uranium Miners Analysis (PUMA) study is the largest uranium miners cohort with 119,709 miners, 4.3 million person-years at risk and 7754 lung cancer deaths. Excess relative rate (ERR) estimates for lung cancer mortality per unit of cumulative exposure to radon progeny in working level months (WLM) based on the PUMA study have been reported.
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