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Enhanced sludge dewaterability and confined antibiotics degradation in biochar-mediated chemical conditioning through modulating Fe oxidative states distribution and reaction sites in multiphase.
Water Res
February 2025
Key laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China. Electronic address:
For antibiotic-enriched waste activated sludge, classical iron-based chemical conditioning significantly enhanced sludge dewaterability. Nevertheless, the intricate constituents within sludge rapidly depleted reactive oxygen species (ROS), leading to challenges such as excessive production of iron sludge and inadequate elimination of antibiotics from sludge. Herein, we proposed an innovative strategy integrating biochar with Fe(II) for peroxymonosulfate (PMS) activation, aiming to enhance both sludge dewaterability and antibiotics elimination simultaneously.
View Article and Find Full Text PDFSulfasalazine-loaded nanoframes: A new frontier in bladder cancer therapy through ferroptosis induction.
Colloids Surf B Biointerfaces
February 2025
Department of Urology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, No.61, west Jiefang Road, Changsha 410011, China. Electronic address:
Promoting ferroptosis in tumor cells has emerged as a promising strategy for cancer therapy. Nonetheless, the heightened antioxidant activity within tumor cells hampers this approach, diminishing its effectiveness and fostering drug resistance. In this study, a new type of sulfasalazine (SAS) loaded nanoframe self-etched Pt-Co nanodendrites (Pt/Co-BNN@SAS) was developed, presenting a novel avenue for inducing ferroptosis in tumor cells by depleting glutathione (GSH) for cancer treatment.
View Article and Find Full Text PDFSodium alginate based fast swelling nanogels for solubility enhancement of chlorthalidone; synthesis, characterization and biosafety evaluation.
Biomed Mater
December 2024
Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Purpose of the study was to enhance the solubility of chlorthalidone, poorly soluble diuretic that has been the used for lowering high blood pressure for the past half-century. Solubility is a challenge for approximately 90% of drug candidates. Chlorthalidone is BCS Class IV drug whose poor solubility needs to be improved in order to optimize its efficacy.
View Article and Find Full Text PDFRosuvastatin/calcium carbonate co-precipitated nanoparticles: A novel synergistic approach enhancing local bone regeneration in osteoporotic rat model.
Int J Pharm
January 2025
Faculty of Pharmacy, Alamein International University, Alamein 51718, Matrouh, Egypt. Electronic address:
This study aimed at preparing sustained release rosuvastatin (Ru) calcium carbonate (CC) co-precipitate nano-formulation for local intra-osseous application in osteoporotic rats. Nano-formulations were prepared by the co-precipitation method using different concentrations of polyvinyl alcohol (PVA) (0.2, 0.
View Article and Find Full Text PDFEfficacy and safety of moderate-intensity rosuvastatin plus ezetimibe versus high-intensity rosuvastatin monotherapy in the treatment of composite cardiovascular events with hypercholesterolemia: A meta-analysis.
PLoS One
November 2024
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China.
Background: Statins are the gold standard in the treatment of dyslipidemia, significantly reducing the risk of cardiovascular disease.
Objective: To systematically review the efficacy and safety of Moderate-intensity Rosuvastatin Plus Ezetimibe compared with High-intensity Rosuvastatin in treating Composite Cardiovascular Events.
Methods: PubMed, Embase, Cochrane Library, CINAHL, Web of Science, China Knowledge Network, China Biological Literature Database, Wan Fang Database, and Weipu Database were searched to retrieve randomized controlled trials assessing the safety and efficacy of the two therapies from the time of construction to December 2023.
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