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A Potential Concomitant Sellar Embryonic Remnant-Associated Collision Tumor: Systematic Review.
Front Oncol
April 2021
Department of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Background: Diagnosing the well-known concomitant Rathke's cleft cyst (RCC) and differentiating it from other sellar lesions are difficult because RCC is and other sellar lesions are closely related and represent a continuum from simple RCCs to more complex lesions. The purpose of this study is to better understand the adeno- and neurohypophysis adjacent to the par intermedia remnants and their role in the origin of the coexistence of these two distinct tumor neoplasias; to assess the incidence in different age groups; to categorize the pathohistological subtype, which can be incorporated in predictive/prognostic models; and finally, to evaluate the current evidence on collision tumors of the sellar embryonic remnant tract in terms of their biological behavior and pathology.
Methods: Utilizing the PubMed database, data were collected from 1920 to 2019.
Hypothalamic Rax tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice.
Nat Commun
April 2021
State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Hypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffusion of blood-born molecules. Tanycytes have recently been considered as potential somatic stem cells in the adult mammalian brain, but their regenerative and tumorigenic capacities are largely unknown. Here we found that Rax+ tanycytes in ME of mice are largely quiescent but quickly enter the cell cycle upon neural injury for self-renewal and regeneration.
View Article and Find Full Text PDFCystic tumors of the pituitary infundibulum: seminal autopsy specimens (1899 to 1904) that allowed clinical-pathological craniopharyngioma characterization.
Pituitary
August 2018
Department of Pathology and Clinical Bacteriology, Jakob Erdheim Institute, Vienna, Austria.
A heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as "pituitary strumas".
View Article and Find Full Text PDFThe Posterior Transpetrosal Approach in a Case of Large Retrochiasmatic Craniopharyngioma: Operative Video and Technical Nuances.
J Neurol Surg B Skull Base
February 2018
Department of Neurosurgery, Hôpital Lariboisière, Paris, France.
To discuss the use of the posterior petrosal approach for the resection of a retrochiasmatic craniopharyngioma. Operative video. In this case video, the authors discuss the surgical management of a large craniopharyngioma, presenting with mass effect on the third ventricle and optic apparatus.
View Article and Find Full Text PDFStem/progenitor cells in pituitary organ homeostasis and tumourigenesis.
J Endocrinol
January 2018
Developmental Biology and Cancer Research ProgrammeBirth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK
Evidence for the presence of pituitary gland stem cells has been provided over the last decade using a combination of approaches including clonogenicity assays, flow cytometric side population analysis, immunohistochemical analysis and genetic approaches. These cells have been demonstrated to be able to self-renew and undergo multipotent differentiation to give rise to all hormonal lineages of the anterior pituitary. Furthermore, evidence exists for their contribution to regeneration of the organ and plastic responses to changing physiological demand.
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