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PKM2 controls cochlear development through lactate-dependent transcriptional regulation.
Proc Natl Acad Sci U S A
January 2025
ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Understanding the role of metabolic processes during inner ear development is essential for identifying targets for hair cell (HC) regeneration, as metabolic choices play a crucial role in cell proliferation and differentiation. Among the metabolic processes, growing evidence shows that glucose metabolism is closely related to organ development. However, the role of glucose metabolism in mammalian inner ear development and HC regeneration remains unclear.
View Article and Find Full Text PDFEffect of A1470T Polymorphism on Lactate and Potassium Concentrations After Caffeine Ingestion During Acute Resistance Exercise.
Nutrients
December 2024
Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, 420012 Kazan, Russia.
Background: The monocarboxylate transporter 1 (MCT1) plays a crucial role in regulating lactate and pyruvate transport across cell membranes, which is essential for energy metabolism during exercise. The A1470T (rs1049434) polymorphism has been suggested to influence lactate transport, with the T (major) allele associated with greater transport efficiency. This study aimed to investigate the effect of the polymorphism on lactate and potassium (K) concentrations in response to resistance exercise (RE) following caffeine (CAF) ingestion.
View Article and Find Full Text PDFSubpopulation-specific gene expression in uncovers distinct metabolic adaptations to wine fermentation.
Curr Res Food Sci
December 2024
Department of Genetics, Physiology and Microbiology, Unit of Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, 28040, Madrid, Spain.
Article Synopsis
- This study investigated gene expression in 23 yeast strains across six subpopulations to understand how winemaking conditions and anthropization influence traits like lactic acid production.
- The analysis showed that different strains have unique transcriptomic profiles linked to fermentation processes, highlighting how anthropized environments lead to metabolic specialization.
- Findings suggest that understanding these gene expression differences can optimize biological acidification and enhance specific traits needed in modern winemaking, such as improved production of lactic acid and other important metabolites.
Key enzymatic activities and metabolic pathway dynamics in acidogenic fermentation of food waste: Impact of pH and organic loading rate.
J Environ Manage
December 2024
College of Engineering (Key Laboratory for Clean Renewable Energy Utilization Technology, Ministry of Agriculture), China Agricultural University, Beijing 100083, PR China. Electronic address:
Acidogenic fermentation was an effective technology to recover volatile fatty acids (VFAs) ethanol and lactic acid from food wastes (FW) as bioresources. However, the impact of process controls on key functional enzymes and metabolic pathways has been inadequately understood. In this study, the metabolite distribution, key functional enzymes and metabolic pathways were completely elucidated using 16S rRNA gene high-throughput sequencing combined with PICRUSt2.
View Article and Find Full Text PDFMetabolomic Profile Modification in the Cerebellum of Mice Repeatedly Exposed to Khat and Treated with β-Lactamase Inhibitor, Clavulanic Acid.
Metabolites
December 2024
Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
Background/objectives: Catha edulis, commonly known as khat, is used for its psychoactive effects and is considered a natural amphetamine. The current study investigated the metabolomic profile in the cerebellum of mice after repeated exposure to khat and evaluated the effects of clavulanic acid on the metabolomic profile in the cerebellum in khat-treated mice.
Methods: Male C67BL/6 mice that were 6-9 weeks old were recruited and divided into three groups: the control group was treated with 0.
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