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Pharmaceutical Nanoplatforms Based on Self-nanoemulsifying Drug Delivery Systems for Optimal Transport and Co-delivery of siRNAs and Anticancer Drugs.
J Pharm Sci
July 2024
Universidad Autónoma del Estado de México, Facultad de Química, Toluca 50120, Estado de México, Mexico. Electronic address:
Small interfering RNAs (siRNAs) have the ability to induce selective gene silencing, although siRNAs are vulnerable to degradation in vivo. Various active pharmaceutical ingredients (APIs) are currently used as effective therapeutics in the treatment of cancer. However, routes of administration are limited due to their physicochemical and biopharmaceutical properties.
View Article and Find Full Text PDFFolic acid and cell-penetrating peptide conjugated PLGA-PEG bifunctional nanoparticles for vincristine sulfate delivery.
Eur J Pharm Sci
September 2012
School of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, China.
Dual- and multi-functional drug delivery systems, especially ligand-modified nanoparticles (NPs) loaded with chemotherapeutic agents are paid much attention to due to their excellent behavior in vitro and in vivo. Bifunctional NPs (BF-NPs), which were based on PLGA-PEG and modified with folic acid and cell penetrating peptide R(7) simultaneously, were developed. BF-NPs loaded with vincristine sulfate (VCR) were prepared via the water-oil-water emulsion solvent evaporation method.
View Article and Find Full Text PDFPoly(lactide-co-glycolide)-laponite-F68 nanocomposite vesicles through a single-step double-emulsion method for the controlled release of doxorubicin.
Langmuir
March 2012
Division of Biosurface Technology, Biomedical Technology (BMT) Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India.
Poly(lactide-co-glycolide) (PLGA)-laponite-F68 nanocomposite (PNC) vesicles were prepared through a technically facile, single-step water/oil/water double-emulsion method using ethyl acetate/water mixture. Vesicles of diameter 100 nm to 1.2 μm and average membrane thickness 30 nm were produced.
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