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Cancer Res
January 2025
Swiss Federal Institute of technology in Lausanne, Lausanne, Vaud, Switzerland.
A recent publication by Bornes and colleagues explored the impact of the estrous cycle on mammary tumor response to neoadjuvant chemotherapy (NAC). Using genetically engineered mouse models, Bornes and colleagues revealed that chemotherapy is less effective when initiated during the diestrus stage compared to during the estrus stage. A number of changes during diestrous were identified that may reduce chemosensitivity of mammary tumors: an increased mesenchymal state of breast cancer cells during diestrous, decreased blood vessel diameters, and higher numbers of macrophages in the tumor microenvironment.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Semmelweisstraße 10, 04103 Leipzig, Germany. Electronic address:
Introduction: Attention-deficit/hyperactivity disorder is a chronic disorder that begins in childhood and often persists into adulthood. There are clinical observations of a cycle-dependent efficacy of psychostimulants in the treatment of ADHD. This relationship appears to be poorly researched.
View Article and Find Full Text PDFTheriogenology
January 2025
UEL - Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address:
This study compared the reproductive performance of three different programs using conventional fixed-time artificial insemination (FTAI), fixed-time embryo transfer (FTET), and their combined use, considering estrus intensity as a criterion for the reproductive program. Brangus multiparous cows (n = 1.100), 40-50 days postpartum, 4-8 years old, and body condition scores 2.
View Article and Find Full Text PDFAnim Reprod Sci
January 2025
University of Georgia, Department of Animal and Dairy Sciences, Athens, GA 30602, USA. Electronic address:
This study evaluated the impact of luteal blood perfusion (BP) and expression of estrus on pregnancy rates of Bos taurus embryo recipients exposed to fixed-timed embryo transfer (FTET) using a gonadotropin-releasing hormone (GnRH)- and progesterone-based ovulation synchronization protocol. Postpartum beef cows (n = 746) were exposed to a GnRH/progesterone-based ovulation synchronization protocol. Luteal morphometry and BP were assessed using color Doppler ultrasonography 9 days after CIDR removal concurrently with FTET.
View Article and Find Full Text PDFArch Gynecol Obstet
January 2025
Reproductive Medicine Research Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, No. 17 Shou-gou-ling Rd., Tianhe District, Guangzhou, 510000, China.
Purpose: To investigate an optimal strategy by assessing the effectiveness of varying follicular sizes on trigger day during luteal phase stimulation protocol and provide evidence for personalized protocol adjustment.
Methods: This was a retrospective study including a total of 661 patients who had started their in vitro fertilization cycle with a luteal phase stimulation (LPS) protocol during 2015-2023. We classified patients into groups according to the size of the dominant proportion of follicles on the human chorionic gonadotropin (hCG) trigger day: large, medium, and small.
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