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Agonists of insect hormones, namely molting hormone (MH) and juvenile hormone (JH), disrupt the normal growth of insects and can be employed as insecticides that are harmless to vertebrates. In this study, a series of experiments and computational analyses were conducted to rationally design novel insect hormone agonists. Syntheses and quantitative structure-activity relationship (QSAR) analyses of two MH agonist chemotypes, imidazothiadiazoles and tetrahydroquinolines, revealed that the structural factors important for the ligand-receptor interactions are significantly different between these chemotypes.
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Graduate School of Infection Control Sciences, Kitasato University.
Our group previously identified MS-347a () as a new fungicide candidate from the culture broth of the mutant strain, sp. KTF-0058, which had the gene inserted. This mutant strain was able to produce a sufficient supply of , allowing for its use to investigate the structure-activity relationship.
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Institute of Chemistry, Vietnam Academy of Science and Technology Hanoi Vietnam
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View Article and Find Full Text PDFHighly sensitive non-enzymatic glucose sensing using Ni nanowires and graphene thin film on the gate area of extended gate electric double-layer field-effect transistor.
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View Article and Find Full Text PDFKey bacterial vaginosis-associated bacteria influence each other's growth in biofilms in rich media and media simulating vaginal tract secretions.
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Bacterial vaginosis (BV) is a very common gynaecologic condition affecting women of reproductive age worldwide. BV is characterized by a depletion of lactic acid-producing species and an increase in strict and facultative anaerobic bacteria that develop a polymicrobial biofilm on the vaginal epithelium. Despite multiple decades of research, the etiology of this infection is still not clear.
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