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Verruciform Acanthotic Vulvar Intraepithelial Neoplasia Harbors Recurrent Genomic Alterations Found in HPV-independent Squamous Cell Carcinoma.
Int J Gynecol Pathol
January 2025
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
The term verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN) was coined to describe HPV-independent p53-wildtype lesions with characteristic clinicopathologic characteristics and association with vulvar squamous cell carcinoma (vSCC). We aimed to expand on the molecular landscape of vaVIN using comprehensive sequencing and copy number variation profiling. vaVIN diagnosis in institutional cases was confirmed by a second review, plus negative p16 and wildtype p53 by immunohistochemistry.
View Article and Find Full Text PDFAn Insight into Dowry Deaths: The Untold Stigma and Torment of a Social Evil.
Cureus
December 2024
Department of Forensic Medicine and Toxicology, Rajendra Institute of Medical Sciences, Ranchi, IND.
Background and objective The institution of marriage is an essential building block of societal structure, acting as a catalyst for joyous celebrations and fresh beginnings. Nonetheless, a persistent problem related to marriage, especially from the viewpoint of women in Indian society, is the dowry system. Despite extensive criticism and opposition, the custom remains prevalent, manifesting in subtle as well as in overt ways.
View Article and Find Full Text PDFMultiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes.
Brain
January 2025
Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, W1W 7FF, UK.
Prions are assemblies of misfolded prion protein that cause several fatal and transmissible neurodegenerative diseases, with the most common phenotype in humans being sporadic Creutzfeldt-Jakob disease (sCJD). Aside from variation of the prion protein itself, molecular risk factors are not well understood. Prion and prion-like mechanisms are thought to underpin common neurodegenerative disorders meaning that the elucidation of mechanisms could have broad relevance.
View Article and Find Full Text PDFParental Attitudes, Motivators and Barriers Toward Children's Vaccination in Poland: A Scoping Review.
Vaccines (Basel)
January 2025
Department of Family and Geriatric Nursing, Faculty of Health Sciences, Medical University of Lublin, Staszica 6 Str., PL-20-081 Lublin, Poland.
Background: Vaccination is one of the most effective ways of protecting individuals against serious infectious diseases and their fatal consequences.
Objectives: The aim of this scoping review was to synthesize data on parental attitudes toward vaccination and identify factors influencing the motivators and barriers to children's vaccination based on Polish studies.
Methods: The scoping review process and reporting were based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScRs) checklist.
A Comparison of the Clinical and Epidemiological Profile of Rocky Mountain Spotted Fever with Dengue and COVID-19 in Hospitalized Children, Sonora, México, 2015-2022.
Trop Med Infect Dis
January 2025
Department of Medicine and Health Sciences, University of Sonora, Ciudad Obregon 85199, Mexico.
Background: Rocky Mountain spotted fever (RMSF) is a challenge for physicians because the disease can mimic other endemic febrile illnesses, such as dengue and COVID-19. The comparison of their main clinical and epidemiological manifestations in hospitalized children can help identify characteristics that improve empirical suspicion and timely therapeutic interventions.
Methods: A cross-sectional study was conducted on a series of patients aged 0 to 18 years, hospitalized between 2015 and 2022, with a diagnosis of RMSF, dengue, or COVID-19.
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