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Evaluation of wound healing activity of hydromethanolic extract of Jacobaea maritima leaves in rabbits.
Pak J Pharm Sci
September 2024
Fatima-Tul-Zahra Department of Life Sciences, Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan.
The study investigated the wound healing efficacy of Jacobaea maritima leaf extract in rabbits through various wound models. A methanol-based extract was prepared from air-dried J. maritima leaves and used to formulate ointments at concentrations of 5%, 10% and 20%.
View Article and Find Full Text PDFEfficacy of neutral electrolyzed water vs. common topical antiseptics in the healing of full‑thickness burn: Preclinical trial in a mouse model.
Biomed Rep
December 2024
Department of Research, Esteripharma SA de CV, Atlacomulco 50450, Mexico.
Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological and emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed solution (SES), with low (SES-low) or high (SES-high) concentrations of active species, alone or in combination with a formulation in gel (G), in comparison with commonly prescribed treatments for burn injury, including nitrofurazone (NF) and silver sulfadiazine (S); normal saline was used as placebo (PI). A scald burn model was established in BALB/c mice.
View Article and Find Full Text PDFResidue Depletion of Nitrofurazone Metabolites, Semicarbazide and 5-Nitro-2-Furaldehyde, in Broiler Chickens After Oral Administration.
J Agric Food Chem
October 2024
ANSES Fougères Laboratory, French Agency for Food, Environment and Occupational Health & Safety, French and European Union Reference Laboratory for Veterinary Medicinal Product Residues and Pharmacologically Active Dye Residues in Food, 10 B rue Claude Bourgelat - Javené, CS 40608, Fougères Cedex 35306, France.
Nitrofurazone (NFZ) antibiotic is banned in food-producing animals, and its metabolite, semicarbazide (SEM), is used as a marker residue for nitrofurazone abuse. However, SEM can also be generated during food processing without veterinary treatment. Therefore, SEM cannot be considered an unequivocal marker of NFZ.
View Article and Find Full Text PDFPotential therapeutic effects of topical recombinant human erythropoietin on burn wound healing: A preliminary randomized double-blind controlled clinical trial.
Burns
December 2024
Clinical Research Center, Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. Electronic address:
Article Synopsis
- The study investigates the effectiveness of topical recombinant human erythropoietin (rhEPO) in improving the healing of burn wounds compared to standard treatments like nitrofurazone/Vitamin A.* -
- Conducted as a randomized double-blind trial with 40 participants, the results showed that those treated with rhEPO had significantly better wound healing outcomes and lower scar formation at follow-up visits.* -
- Overall, the findings suggest that topical rhEPO is a promising treatment for burn wounds, enhancing patient satisfaction without severe side effects.*
[Allergic contact dermatitis due to Furacin®].
Rev Alerg Mex
June 2024
Servicio de Alergología, Hospital Punta Europa, Algeciras (Cádiz), España.
Article Synopsis
- A 57-year-old male developed a skin rash and blisters shortly after using Furacin®, a topical treatment containing nitrofurazone, for an infected wound.
- Epicutaneous testing confirmed an allergy to nitrofurantoin, a component of the treatment, after 96 hours.
- The case highlights the importance of considering both the active ingredients and excipients in topical medications when adverse reactions occur.
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