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The fetal-maternal interface of the nine-banded armadillo: endothelial cells of maternal sinus are partially replaced by trophoblast.
Zoological Lett
June 2016
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT USA ; Yale Systems Biology Institute, Yale University, West Haven, CT USA ; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale Medical School, New Haven, CT USA ; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI USA.
Background: The evolution of invasive placentation in the stem lineage of eutherian mammals entailed resolution of the incompatibility between a semi-allogenic fetus and the maternal immune system. The haemochorial placenta of nine-banded armadillo (Dasypus novemcinctus) is thought to conceal itself from the maternal immune system to some degree by developing inside a preformed blood sinus, with minimal contact with the uterine connective tissue. In the present study, we elucidate the micro-anatomical relationship between fetal and maternal tissue of the nine-banded armadillo using histochemical and immunohistochemical tools.
View Article and Find Full Text PDFDecidual vasculopathy and adverse perinatal outcome in preeclamptic pregnancy.
Placenta
August 2012
Radboud University Nijmegen Medical Centre, Department of Obstetrics & Gynaecology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Objective: Decidual vasculopathy (DV) describes pathological findings seen in the spiral arteries in preeclampsia (PE). Morphologically, DV is characterized by fibrinoid necrosis and foamy macrophages within the vessel walls. The impact of the lesions on clinical outcome and placental pathology is unclear.
View Article and Find Full Text PDFShifting concepts of the fetal-maternal interface: a historical perspective.
Placenta
March 2008
Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium.
The first microscopic images of the human placenta, obtained in the 1830s, revealed the presence of an epithelial lining separating fetal capillaries from maternal blood, which was in later years successively interpreted as maternal endothelial, decidual and finally as "trophoblastic". With this new term, introduced by Hubrecht in 1889, its embryonic/fetal origin was recognized as well as its role in nutrient uptake from maternal blood. Thomas Huxley considered the presence of a decidua as an important feature for mammalian classification, but still mixed up maternal and trophoblastic tissue.
View Article and Find Full Text PDFControl of human trophoblast function.
Reprod Biol Endocrinol
February 2007
Department of Biology, Section of General Physiology, University of Ferrara, 44100 Ferrara, Italy.
The trophoblast, i.e. the peripheral part of the human conceptus, exerts a crucial role in implantation and placentation.
View Article and Find Full Text PDFFibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse.
Am J Pathol
March 2002
W. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
In humans, maternal fibrinogen (Fg) is required to support pregnancies by maintaining hemostatic balance and stabilizing uteroplacental attachment at the fibrinoid layer found at the fetal-maternal junction. To examine relationships between low Fg levels and early fetal loss, a genetic model of afibrinogenemia was developed. Pregnant mice homozygous for a deletion of the Fg-gamma chain, which results in a total Fg deficiency state (FG(-/-)), aborted the fetuses at the equivalent gestational stage seen in humans.
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