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Actinomycosis masquerading as a nasal polyp - a rare entity and diagnostic challenge.
GMS Hyg Infect Control
December 2024
Department of ENT, Sree Balaji Medical college Chromepet, Chennai, Tamil Nadu, India.
Actinomycosis is an endogenous bacterial infection caused by . This bacterium reside on the mucosa of oral cavity, tonsils, and genitourinary tract. Any insult such as trauma, surgery, or foreign body disrupts the mucosal barrier and gives entry to the underlying tissue to cause disease.
View Article and Find Full Text PDFRapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
A proposal for analyzing the inflammatory and remodeling processes of mucosa in chronic rhinosinusitis with nasal polyposis through MRI.
Braz J Otorhinolaryngol
November 2024
Universidade Federal de São Paulo, Departamento de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil; University of British Columbia, Division of Rhinology, Vancouver, Canada.
Objectives: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a disease characterized by chronic inflammation and tissue remodeling process. The remodeling process in nasal polyps has mainly been studied by histology analysis. However, it is limited to a polyp fragment and requires tissue removal.
View Article and Find Full Text PDFMelanocytic Nevus With Spindle Cell Lipomatous Metaplasia.
Am J Dermatopathol
August 2024
Dermatopathology Study Center of Florence, Florence, Italy; and.
Article Synopsis
- Melanocytic nevi can vary greatly in their structure, sometimes leading to diagnostic challenges, especially with unusual histopathological patterns.
- A 22-year-old woman had a poorly pigmented scalp lesion that was identified as an intradermal melanocytic nevus, showing benign melanocytes in unique formations along with collagen-rich stroma and lipomatous areas.
- The study highlights the rare occurrence of spindle cell lipomatous metaplasia within melanocytic nevi, expanding the understanding of potential stromal variations in these skin lesions.
[ALK rearranged Spitz melanocytoma: a clinicopathological and molecular genetic analysis of two cases].
Zhonghua Bing Li Xue Za Zhi
August 2024
Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Article Synopsis
- The study investigates the characteristics of cutaneous ALK-rearranged Spitz melanocytoma through clinical, molecular, and immunohistochemical analysis of two pediatric cases.
- Both cases, involving an 8-year-old boy and an 11-year-old girl, presented with skin lesions and exhibited specific histological features, including medium to large-sized neoplastic cells with distinct cytoplasm and nuclear characteristics.
- The tumors showed strong positivity for certain immunohistochemical markers and confirmed ALK-rearrangement through genetic analysis, indicating a unique subset of Spitz melanocytoma primarily found in children and adolescents, with a favorable prognosis post-resection.
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