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Racial disparities in neuropsychological test performance are well documented in Alzheimer's Disease (AD) but have received little attention in frontotemporal degeneration (FTD). Identification of potential disparities in neuropsychological performance is critical to identify ways to improve inclusivity in clinical research and care of representative FTD populations. We evaluated disparities in neuropsychological performance among individuals with clinically diagnosed FTD (behavioral variant FTD [bvFTD] or primary progressive aphasia [PPA]) using data from the National Alzheimer's Coordinating Center (NACC) collected between September 2005 and November 2023.
View Article and Find Full Text PDFDifferences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.
Alzheimers Dement
January 2025
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Introduction: Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD.
Methods: Z-score cognitive-domain composites for 311 amyloid-positive sporadic EOAD and 314 amyloid-positive LOAD participants were calculated from baseline data from age-appropriate control cohorts.
Delayed cyst formation after radiosurgery for arteriovenous malformation: A case report and critical review.
Surg Neurol Int
October 2024
Neurosurgery Department, Unidade Local de Saúde de São João (ULS São João), Oporto, Portugal.
Background: Stereotactic radiosurgery (SRS) is a validated treatment option for cerebral arteriovenous malformations (AVMs), even if a greater knowledge of its potential delayed complications is still being acquired.
Case Description: A 49-year-old man suffered multiple episodes of cerebral hemorrhage in an approximate 10-year follow-up interval in the context of a left central core AVM with deep venous drainage into the internal cerebral veins (Spetzler Martin Grade 4) despite being treated with gamma knife radiosurgery at two separate timepoints, and with an almost complete obliteration confirmed. Approximately 10 years after the first radiosurgery treatment, he developed severe motor aphasia, Grade 3 right hemiparesis, progressive confusion, and memory deficits.
Ovarian teratoma-associated Anti-NMDAR encephalitis in women with first-time neuropsychiatric symptoms: A meta-analysis and systematic review of reported cases.
Heliyon
October 2024
Department of Gynecology and Urogynecology, Andrzej Frycz Modrzewski Krakow University, Kraków, Poland.
Objective: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is frequently associated with ovarian teratomas. The diverse clinical presentations and several stages of disease development pose a significant diagnostic challenge for clinicians. The main objective of this research was to show the prevalence of neuropsychiatric symptoms of ovarian-teratoma-associated anti-NMDAR encephalitis and to highlight the importance of multidisciplinary collaboration in the diagnosis, treatment, and prevention of disease progression.
View Article and Find Full Text PDFCerebral air embolism following a hemodialysis session successfully treated with hyperbaric oxygen: a case report.
Ther Adv Neurol Disord
October 2024
Department of Nephrology, Dialysis, and Transplantation, Amiens University Hospital, University of Picardie Jules Verne, F-80054 Amiens, France.
Article Synopsis
- A 39-year-old woman developed cerebral air embolism (CAE) during hemodialysis due to a faulty central venous catheter, which can be a rare but serious complication, especially affecting the brain.
- She initially presented with a seizure and was monitored in the Intensive Care Unit, later experiencing worsening symptoms such as aphasia and hemiplegia before being treated with hyperbaric oxygen therapy (HBOT).
- After three sessions of HBOT, she fully recovered, with post-treatment seizures linked to hyperoxia, underscoring the need for vigilant monitoring and immediate treatment in lung transplant patients undergoing hemodialysis.
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