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Identification of immune-related signatures and pathogenesis differences between thoracic aortic aneurysm patients with bicuspid versus tricuspid valves via weighted gene co-expression network analysis.
PLoS One
October 2023
Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang, China.
Background: Thoracic aortic aneurysm (TAA) occurs due to pathological aortal dilation, and both individuals with normal tricuspid aortic valves (TAV) or abnormal bicuspid aortic valves (BAV), the latter being a congenital condition, are at risk. However, some differences are present between TAA/BAV and TAA/TAV with respect to their pathophysiological processes and molecular mechanisms, but their exact nature is still mostly unknown. Therefore, it is necessary to elucidate TAA developmental differences among BAV vs.
View Article and Find Full Text PDFOcclusion of the venous or arterial vessels in childhood is rather rare but dangerous complication. Occurrence of neonatal thrombosis is 0.5 per 10 000 of live newborns.
View Article and Find Full Text PDFThe Origin of a New Progenitor Stem Cell Group in Human Development.
Adv Anat Embryol Cell Biol
March 2020
Department of Cellular and Molecular Medicine, University of Copenhagen, København N, Denmark.
The observation of two precursor groups of the early stem cells (Groups I and II) leads to the realization that a first amount of fetal stem cells (Group I) migrate from the AMG (Aortal-Mesonephric-Gonadal)-region into the aorta and its branching vessels. A second group (Group II) gains quite a new significance during human development. This group presents a specific developmental step which is found only in the human.
View Article and Find Full Text PDFCongenital incomplete fusion of superior mesenteric artery mimicking dissection.
Am J Case Rep
January 2015
Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore.
Background: Both spontaneous SMA dissection and anatomical variants of GIT vasculature are well known entities. We present a case initially diagnosed as an SMA dissection on CT, but upon detailed review of the imaging findings was considered to be incompletely fused ventral segmental arteries--a rare anatomic variant not well described before. This finding is clinically significant, as it can mimic a vascular dissection and such a wrong diagnosis will lead to unnecessary investigation and intervention.
View Article and Find Full Text PDFAmong 46 patients 39 died of cardial cause and 7--noncardial one. Chlamydia pneumonia (Ch-p) was founded out in aortal endothelium of 26 studied patients. Only 3 patients (11%) had the typical form of inclusions, 23 cases (89% of infected patients) had persistent form of inclusions in aortal endothelium.
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