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Prioritizing performance and outcome indicators for quality assessment of cancer screening programs in the EU.
Public Health
January 2025
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Objectives: A key element in ensuring appropriate balance of harms and benefits in cancer screening is to develop a priority set of performance and outcome indicators to be used in screening data evaluation systems. These indicators need to be equity-focused, aligned to new screening approaches and broad-based to cover possible opportunistic screening, but at the same time as limited as possible.
Study Design: Indicators for breast, colorectal and cervical cancer screening programs were chosen through a consensus building Delphi methodology involving a panel of cancer screening experts.
Drug Target Investigation of --Coumaroyl-'-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from .
Antioxidants (Basel)
December 2024
School of Biotechnology, Jiangnan University, Wuxi 214122, China.
The exploration of drug targets has always been a priority in new drug research, and this work is even more essential for natural active compounds. is a traditional Tibetan medicine with excellent antioxidant properties. In this study, an alkaloid, --coumaroyl-'-caffeoylputrescine (PCC), was first isolated from the plant, , with a DPPH scavenging rate of 0.
View Article and Find Full Text PDFDigoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial.
Nat Med
January 2025
Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety of cancer types. In breast cancer, preclinical studies showed that inhibitors of the Na/K ATPase suppress CTC clusters and block metastasis. Here we conducted a prospective, open-label, proof-of-concept study in women with metastatic breast cancer, where the primary objective was to determine whether treatment with the Na/K ATPase inhibitor digoxin could reduce mean CTC cluster size.
View Article and Find Full Text PDFResistance to Radiotherapy in Cancer.
Diseases
January 2025
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Radiation therapy or radiotherapy is a medical treatment that uses high doses of ionizing radiation to eliminate cancer cells and shrink tumors. It works by targeting the DNA within the tumor cells restricting their proliferation. Radiotherapy has been used for treating cancer for more than 100 years.
View Article and Find Full Text PDFTherapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.
Adv Sci (Weinh)
January 2025
Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, P. R. China.
Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells.
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