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GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations.
J Mass Spectrom Adv Clin Lab
November 2023
Hannover Medical School, Institute of Toxicology, Core Unit Proteomics, 30623 Hannover, Germany.
Malondialdehyde (MDA; 1,3-propanedial, OHC-CH-CHO) is one of the most frequently measured biomarkers of oxidative stress in plasma and serum. L-Arginine (Arg) is the substrate of nitric oxide synthases (NOS), which convert L-arginine to nitric oxide (NO) and L-citrulline. The Arg/NO pathway comprises several members, including the endogenous NOS-activity inhibitor asymmetric dimethylarginine (ADMA) and its major metabolite dimethyl amine (DMA), and nitrite and nitrate, the major NO metabolites.
View Article and Find Full Text PDFN-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
Amino Acids
September 2022
Clinic for Rheumatology und Immunology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
N-Acetyl-L-cysteine (NAC) is an endogenous cysteine metabolite. The drug is widely used in chronic obstructive pulmonary disease (COPD) and as antidote in acetaminophen (paracetamol) intoxication. Currently, the utility of NAC is investigated in rheumatoid arthritis (RA), which is generally considered associated with inflammation and oxidative stress.
View Article and Find Full Text PDFPharmacogenomic considerations for immunosuppressive therapy.
Pharmacogenomics
May 2003
Department of Nephrology and Hypertension, Faculty of Health Sciences, Ben-Gurion University Barzilai Medical Center Campus, Ashkelon 78306, Israel.
Immunosuppression, the art of suppressing the endogenous immune system to allow organ transplantation or treatment of autoimmune disease, is a clinico-pharmacological field that has markedly developed over the past three decades with the advent of highly potent and rationally targeted immunosuppressive agents. Pharmacogenomics, the art of providing tailored pharmacological therapy with the highest therapeutic index based on the genomic composition of the individual, is a science that has rapidly developed over the past decade, along with the advances in the human genome project and in biotechnology. Pharmacogenomics of immunosuppression is the combined art of tailoring specific immunosuppressive drug therapy to specific immune-mediated clinical entities which require immunosuppression, with optimum matching of the drug to the individual's genomic makeup.
View Article and Find Full Text PDF[Clinico-pharmacological case (4). Epileptic seizure as an unwanted drug effect on theophylline poisoning].
Praxis (Bern 1994)
October 1996
Abteilung Klinische Pharmakologie, Departement Innere Medizin, Kantonsspital Basel.
In spite of the better understanding of the pharmacokinetics and optimized galenics of oral theophylline formulations, therapy with this bronchodilator still bears risks because of its narrow therapeutic window combined with substantial inter- and intra-individual variability of theophylline metabolism. In particular, the comedication with a variety of drugs inhibiting theophylline metabolism requires consideration as a potential source of toxicity. Besides mild, self-limited adverse effects, potentially life-threatening toxic manifestations such as ventricular tachyarrhythmias, shock, and seizures can occur especially with high plasma concentrations.
View Article and Find Full Text PDFHuman tolerability and pharmacodynamic study of Tisacid tablet in duodenal ulcer patients. A prospective, randomized, self-controlled clinicopharmacological study.
Acta Med Hung
June 1989
1st Department of Medicine, University Medical School, Pécs, Hungary.
A randomized, prospective, crossing-over clinico-pharmacological study was conducted on the tolerability by humans, of TISACID (Al-Mg-hydroxy-carbonate), a new antacid of up-to-date composition produced in Hungary. Even a relatively high dose of the preparation is tolerated by the human organism. During a 6-week continuous treatment neither subjective nor objective side-effects were observed.
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