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Effects of Intravenous Hydroxyzine Versus Haloperidol Monotherapy for Delirium: A Retrospective Study.
J Clin Psychiatry
January 2025
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, Division of Drug Informatics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Although antipsychotics are used commonly for delirium, they increase the risk of mortality in elderly patients and those with dementia. As hydroxyzine has sedative and anxiolytic effects, it can be used in the treatment of delirium. We performed a retrospective study to compare the effects of intravenous hydroxyzine and haloperidol monotherapy on delirium.
View Article and Find Full Text PDFPreventive Effect of Hydroxyzine on Postoperative Nausea and Vomiting: A Single-Center, Retrospective, Observational Cohort Study.
J Clin Med
December 2024
Department of Anesthesiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Fukuoka, Japan.
Postoperative nausea and vomiting (PONV) is a common and distressing complication after surgery. Hydroxyzine, an affordable histamine H1 receptor antagonist with anxiolytic, moderate sedative, and antiemetic properties, is often used perioperatively; however, few studies have investigated its effect on PONV. In this study, we examined the efficacy of hydroxyzine in preventing PONV.
View Article and Find Full Text PDFAssessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System.
J Am Geriatr Soc
January 2025
Department of Pharmacy, Charpennes Hospital, Hospices Civils de Lyon, Villeurbanne, France.
Background: In older people, medications with anticholinergic or sedative properties are associated with falls, frailty, and functional and cognitive impairment. These medications are often described as a subset of potentially inappropriate medications (PIMs). We examined the prevalence of anticholinergic or sedative medications to avoid in older people in France in 2023.
View Article and Find Full Text PDFUsing Zebrafish G Protein-Coupled Receptors to Obtain a Better Appreciation of the Impact of Pharmaceuticals in Wastewater to Fish.
Environ Sci Technol
January 2025
Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Otsu, Shiga 520-0811, Japan.
Pharmaceutical discharge to the environment is of concern due to its potential adverse effects on aquatic species. It is estimated that around 40% of pharmaceuticals target G protein-coupled receptors (GPCRs). The transforming growth factor- (TGF) shedding assay was applied to measure the antagonistic activities of pharmaceuticals against human GPCRs.
View Article and Find Full Text PDFProbing the Histamine H Receptor Binding Site to Explore Ligand Binding Kinetics.
J Med Chem
January 2025
Amsterdam Institute of Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Analysis of structure-kinetic relationships (SKR) can contribute to an improved understanding of receptor-ligand interactions. Here, fragment (4-(2-benzylphenoxy)-1-methylpiperidine) was used in different fragment growing approaches to mimic the putative binding mode of the long residence time (RT) ligands olopatadine, acrivastine, and levocetirizine at the histamine H receptor (HR). SKR analyses reveal that introduction of a carboxylic acid moiety can increase RT at HR up to 11-fold.
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